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 Publications

2024

Publications—2024

Peer-Reviewed Journal Articles (Original Research)

  1. Synthetic collagen hydrogels through symmetric self-assembly of small peptides. I. Caglar Tanrikulu, Lianna Dang, Lekha Nelavelli, Aubrey J. Ellison, Bradley D. Olsen, Song Jin, and Ronald T. Raines (2024). Advanced Science 11, 2303228. [PubMed] [PDF] [SuppInfo]
  2. Click organocatalysis: Acceleration of azide–alkyne cycloadditions with mutually orthogonal click reactions. Brian J. Levandowski, Brian J. Graham, K. N. Houk, and Ronald T. Raines (2024). Journal of Organic Chemistry 89, 2232–2237. [PubMed] [PDF] [SuppInfo]
  3. Sensitive detection of SARS-CoV-2 main protease 3CLpro with an engineered ribonuclease zymogen. Evans C. Wralstad and Ronald T. Raines (2024). Protein Science 33, e4916. [PubMed] [PDF] [SuppInfo] [Video]
  4. Evaluation of the cytosolic uptake of HaloTag using a pH-sensitive dye. JoLynn B. Giancola, Jonathan B. Grimm, Joomyung V. Jun, Yana D. Petri, Luke D. Lavis, and Ronald T. Raines (2024). ACS Chemical Biology 19, 908–915. [PubMed] [PDF] [SuppInfo]
  5. Taming the 1,5-sigmatropic shift across protonated spirocyclic 4H‑pyrazoles. Brian J. Levandowski, Brian J. Graham, Nile S. Abularrage, and Ronald T. Raines (2024). Journal of Physical Organic Chemistry 37, e4642. [PubMed] [PDF] [SuppInfo]
  6. Facile access to branched multi-specific proteins. Aniekan Okon, Jinyi Yang, JoLynn B. Giancola, Oscar J. Molina, Jessica Sayers, Keith M. Cheah, Yanfeng Li, Eric R. Strieter, and Ronald T. Raines (2024). Bioconjugate Chemistry 35, 954–962. [PubMed] [PDF] [SuppInfo]
  7. Pentaphosphorylation via the anhydride of dihydrogen pentametaphosphate: Access to nucleoside hexa- and heptaphosphates and study of their interaction with ribonuclease A. Gyeongjin Park; Evans C. Wralstad; Noelia Faginas-Lago, Kevin Quan, Ronald T. Raines, Giovanni Bistoni, and Christopher C. Cummins (2024). ACS Central Science 10, 1415–1422. [PubMed] [PDF] [SuppInfo]
  8. Peptidic “molecular beacon” for collagen. Jinyi Yang, Yifan Quan, Yifu Ouyang, Kong Ooi Tan, Ralph T. Weber, Robert G. Griffin, and Ronald T. Raines (2024). Biomacromolecules 25, 6773–6779. [PubMed] [PDF] [SuppInfo]
  9. Mammalian esterase activity: Implications for peptide prodrugs. Yana D. Petri, Ruben Verresen, Clair S. Gutierrez, Volga Kojasoy, Erika Zhang, Nile S. Abularrage, Evans C. Wralstad, Kaya R. Weiser, and Ronald T. Raines (2024). Biochemistry 63, 2580–2593. [PubMed] [PDF] [SuppInfo]
  10. Pauli exclusion by n→π* interactions: Implications for paleobiology. Jinyi Yang, Volga Kojasoy, Gerard J. Porter, and Ronald T. Raines (2024). ACS Central Science 10, 1829–1834. [PubMed] [PDF] [SuppInfo]
  11. Sitetack: A deep learning model that improves PTM prediction by using known PTMs. Clair S. Gutierrez, Alia A. Kassim, Benjamin D. Gutierrez, and Ronald T. Raines (2024). Bioinformatics, In Press. (Preprint DOI: 10.1101/2024.06.03.596298.) [PubMed]
  12. An unanticipated, outcome-defining role for the triple-helical domain in resulting procollagen-I assembly. Kathryn M. Yammine, Rasia C. Li, Isabella M. Borgula, Sophia Mirda Abularach, Andrew S. DiChiara, Ronald T. Raines, and Matthew D. Shoulders (2024). Proceedings of the National Academy of Sciences, U.S.A., In Press.

Peer-Reviewed Journal Articles (Reviews)

  1. COVER ARTICLE Emergent organoboron acid catalysts. Brian J. Graham and Ronald T. Raines (2024). Journal of Organic Chemistry 89, 2069–2089. [PubMed] [PDF]
  2. Chemoselective reagents for the traceless bioreversible modification of native proteins. Yana D. Petri, Forrest G. FitzGerald, and Ronald T. Raines (2024). Bioconjugate Chemistry 35, 1300–1308. [PubMed] [PDF]

Preprints

  1. Identifying and targeting key driver genes for collagen production within the 11q13/14 breast cancer amplicon. Daniela Araiza-Olivera, Tatiana Y. Prudnikova, Cristina Uribe-Alvarez, Kathy Q. Cai, Janusz Franco-Barraza Jesús M. Dones, Ronald T. Raines, and Jonathan Chernoff (2024). bioRxiv 2024.03.27.587019.
  2. Sitetack: A deep learning model that improves PTM prediction by using known PTMs. Clair S. Gutierrez, Alia A. Kassim, Benjamin D. Gutierrez, and Ronald T. Raines (2024). bioRxiv 2024.06.03.596298.
  3. Endosomolytic peptides enable the cellular delivery of peptide nucleic acids. JoLynn B. Giancola and Ronald T. Raines (2024). bioRxiv 2024.06.18.599558.
2023

Publications—2023

Peer-Reviewed Journal Articles (Original Research)

  1. Nα-Methylation of arginine: Implications for cell-penetrating peptides. Lindsey O. Calabretta, Jinyi Yang, and Ronald T. Raines (2023). Journal of Peptide Science 29, e3468. [PubMed] [PDF] [SuppInfo]
  2. COVER ARTICLE Spirocyclization enhances the Diels–Alder reactivities of geminally substituted cyclopentadienes and 4H-pyrazoles. Brian J. Levandowski, Nile S. Abularrage, and Ronald T. Raines (2023). Journal of Physical Organic Chemistry 36, e4478. [PubMed] [PDF] [SuppInfo]
  3. Inhibition of HIV-1 protease by a boronic acid with high oxidative stability. Brian J. Graham, Ian W. Windsor, and Ronald T. Raines (2023). ACS Medicinal Chemistry Letters 14, 171–175. [PubMed] [PDF] [SuppInfo]
  4. Modular diazo compound for the bioreversible late-stage modification of proteins. Joomyung V. Jun, Yana D. Petri, Lucas W. Erickson, and Ronald T. Raines (2023). Journal of the American Chemical Society 145, 6615–6621. [PubMed] [PDF] [SuppInfo]
  5. COVER ARTICLE Bioorthogonal 4H-pyrazole “click” reagents. Nile S. Abularrage, Brian J. Levandowski, JoLynn B. Giancola, Brian J. Graham, and Ronald T. Raines (2023). Chemical Communications 59, 4451–4454. [PubMed] [PDF] [SuppInfo]
  6. Chemoselective caging of carboxyl groups for on-demand protein activation with small molecules. Yana D. Petri, Clair S. Gutierrez, and Ronald T. Raines (2023). Angewandte Chemie International Edition 62, e202215614. [PubMed] [PDF] [SuppInfo]
  7. Differential membrane binding of α/β-peptide foldamers: Implications for cellular delivery and mitochondrial targeting. Tzong-Hsien Lee, James W. Checco, Tess Malcolm, Chelcie H. Eller, Ronald T. Raines, Samuel H. Gellman, Erinna F. Lee, W. Douglas Fairlie, and Marie-Isabel Aguilar (2023). Australian Journal of Chemistry 76, 482–492. [PubMed] [PDF] [SuppInfo]
  8. Fluorescent guanidinium-azacarbazole for oxoanion binding in water. Lindsey O. Calabretta, Yana D. Petri, and Ronald T. Raines (2023). Journal of Organic Chemistry 88, 11694–11701. [PubMed] [PDF] [SuppInfo]
  9. Bayesian inference elucidates the catalytic competency of the SARS-CoV-2 main protease 3CLpro. Evans C. Wralstad, Jessica Sayers, and Ronald T. Raines (2023). Analytical Chemistry 95, 14833–14840. [PubMed] [PDF] [SuppInfo]
  10. Computational study of an oxetane 4H-pyrazole as a Diels–Alder diene. Brian J. Levandowski, Nile S. Abularrage, Brian J. Graham, and Ronald T. Raines (2023). Tetrahedron Letters 130, 154768. [PubMed] [PDF] [SuppInfo]
  11. Detection of pulmonary fibrosis with a collagen-mimetic peptide. Isabella M. Borgula, Sergey Shuvaev, Eric Abston, Nicholas J. Rotile, Jonah Weigand-Whittier, Iris Y. Zhou, Peter Caravan, and Ronald T. Raines (2023). ACS Sensors 8, 4008–4013. [PubMed] [PDF] [SuppInfo]
2022

Publications—2022

Peer-Reviewed Journal Articles (Original Research)

  1. Bifunctional peptide that anneals to damaged collagen and clusters TGF-β receptors enhances wound healing. Sayani Chattopadhyay, Leandro B. C. Teixeira, Laura L. Kiessling, Jonathan F. McAnulty, and Ronald T. Raines (2022). ACS Chemical Biology 17, 314–321. [PubMed] [PDF] (Preprint DOI: 10.1101/2021.09.22.461420.)
  2. Canavanine versus arginine: Prospects for cell-penetrating peptides. Lindsey O. Calabretta, Vienna M. Thomas, and Ronald T. Raines (2022). Tetrahedron Letters 99, 153848. [PubMed] [PDF] [SuppInfo]
  3. Context-dependence of the reactivity of cysteine and lysine residues. Linus B. Boll and Ronald T. Raines (2022). ChemBioChem 23, e202200258. [PubMed] [PDF] [SuppInfo]
  4. Host–guest complexation by β-cyclodextrin enhances the solubility of an esterified protein. Keith M. Cheah, Joomyung V. Jun, K. Dane Wittrup, and Ronald T. Raines (2022). Molecular Pharmaceutics 19, 3869–3876. [PubMed] [PDF] [SuppInfo]

Peer-Reviewed Journal Article (Review)

  1. Emerging biological functions of ribonuclease 1 and angiogenin. Emily R. Garnett and Ronald T. Raines (2022). Critical Reviews in Biochemistry and Molecular Biology 57, 244–260. [PubMed] [PDF]

Invited Journal Article

  1. Assessing and utilizing esterase specificity in antimicrobial prodrug development. Kenton J. Hetrick and Ronald T. Raines (2022). Methods in Enzymology 664, 199–220. [PubMed] [PDF]
2021

Publications—2021

Peer-Reviewed Journal Articles (Original Research)

  1. Semisynthesis of human ribonuclease–S. Jessica Sayers, Evans C. Wralstad, and Ronald T. Raines (2021). Bioconjugate Chemistry 32, 82–87. [PubMed] [PDF] [Supporting Information]
  2. Boronic acid with high oxidative stability and utility in biological contexts. Brian J. Graham, Ian W. Windsor, Brian Gold, and Ronald T. Raines (2021). Proceedings of the National Academy of Sciences, U.S.A. 118, e2013691118. [PubMed] [PDF] [Supporting Information] (Preprint DOI: 10.26434/chemrxiv.13337399.v1.)
  3. Two-step synthesis of α-aryl-α-diazoamides as modular bioreversible labels. Joomyung V. Jun and Ronald T. Raines (2021). Organic Letters 23, 3110–3114. [PubMed] [PDF] [Supporting Information]
  4. Endogenous enzymes enable antimicrobial activity. Kenton J. Hetrick, Miguel A. Aguilar Ramos, and Ronald T. Raines (2021). ASC Chemical Biology 16, 800–805. [PubMed] [PDF] [Supporting Information]
  5. Geminal repulsion disrupts Diels–Alder reactions of geminally substituted cyclopentadiene and 4H-pyrazoles. Brian J. Levandowski, Nile S. Abularrage, and Ronald T. Raines (2021). Tetrahedron 91, 132160. [PubMed] [PDF] [Supporting Information]
  6. Acceleration of 1,3-dipolar cycloadditions by integration of strain and electronic tuning. Jesús M. Dones, Nile S. Abularrage, Namrata Khanal, Brian Gold, and Ronald T. Raines (2021). Journal of the American Chemical Society 143, 9489–9497. [PubMed] [PDF] [Supporting Information]
  7. Ribonuclease zymogen induces cytotoxicity upon HIV-1 infection. Ian W. Windsor, Dawn M. Dudley, David H. O’Connor, and Ronald T. Raines (2021). AIDS Research and Therapy 18, 77. [PubMed] [PDF] [Supporting Information

Peer-Reviewed Journal Article (Review)

  1. Click chemistry with cyclopentadiene. Brian J. Levandowski and Ronald T. Raines (2021). Chemical Reviews 121, 6777–6801. [PubMed] [PDF]

Preprint

  1. Bifunctional peptide that anneals to damaged collagen and clusters TGF-β receptors enhances wound healing. Sayani Chattopadhyay, Leandro B. C. Teixeira, Laura L. Kiessling, Jonathan F. McAnulty, and Ronald T. Raines (2021). bioRxiv 2021.09.22.461420.
2020

Publications—2020

Peer-Reviewed Journal Articles (Original Research)

  1. Templated collagen “double helices” maintain their structure. I. Caglar Tanrikulu, William M. Westler, Aubrey J. Ellison, John L. Markley, and Ronald T. Raines (2020). Journal of the American Chemical Society 142, 1137–1141. [PubMed] [PDF] [Supporting Information]
  2. Stereoelectronic effects impact glycan recognition. Caitlin M. McMahon, Christine R. Isabella, Ian W. Windsor, Paul Kosma, Ronald T. Raines, and Laura L. Kiessling (2020). Journal of the American Chemical Society 142, 2386–2395. [PubMed] [PDF] [Supporting Information] (Preprint DOI: 10.26434/chemrxiv.11541927.v1.)
  3. Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme. Lindsey R. F. Backman, Yolanda Y. Huang, Michael A. Funk, Brian Gold, Ronald T. Raines, Emily P. Balskus, and Catherine L. Drennan (2020). eLife 9, e51420. [PubMed] [PDF]
  4. Hox genes maintain critical roles in the adult skeleton. Jane Y. Song, Kyrie M. Pineaultz, Jesús M. Dones, Ronald T. Raines, and Deneen M. Wellik (2020). Proceedings of the National Academy of Sciences, USA 117, 7296–7304. [PubMed] [PDF] [Supporting Information]
  5. Cyclic peptide mimetic of damaged collagen. Aubrey J. Ellison, I. Caglar Tanrikulu, Jesús M. Dones, and Ronald T. Raines (2020). Biomacromolecules 21, 1539–1547. [PubMed] [PDF] [Supporting Information]
  6. Disulfide chromophores arise from stereoelectronic effects. Henry R. Kilgore and Ronald T. Raines (2020). Journal of Physical Chemistry B 124, 3931–3935. [PubMed] [PDF] [Supporting Information
  7. Synthesis and Diels–Alder reactivity of 4-fluoro-4-methyl-4H-pyrazoles. Nile S. Abularrage, Brian J. Levandowski, and Ronald T. Raines (2020). International Journal of Molecular Sciences 21, E3964. [PubMed] [PDF] [Supporting Information]
  8. Role for cell-surface collagen of Streptococcus pyogenes in infections. Aubrey J. Ellison, Felix Dempwolff, Daniel B. Kearns, and Ronald T. Raines (2020). ACS Infectious Diseases 6, 1836–1843. [PubMed] [PDF] [Supporting Information]
  9. COVER ARTICLE Differential effects of nitrogen substitution in 5- and 6-membered aromatic motifs. Brian J. Levandowski, Nile S. Abularrage, and Ronald T. Raines (2020). Chemistry—A European Journal 26, 8862–8866. [PubMed] [PDF] [Supporting Information]
  10. Structure and dynamics of N-glycosylated human ribonuclease 1. Henry R. Kilgore, Andrew P. Latham, Valerie T. Ressler, Bin Zhang, and Ronald T. Raines (2020). Biochemistry 59, 3148–3156. [PubMed] [PDF] [Supporting Information]
  11. n→π* Interactions modulate the disulfide reduction potential of epidithiodiketopiperazines. Henry R. Kilgore, Chase R. Olsson, Kyan A. D’Angelo, Mohammad Movassaghi, and Ronald T. Raines (2020). Journal of the American Chemical Society 142, 15107–15115. [PubMed] [PDF] [Supporting Information]
  12. Triple, mutually orthogonal bioorthogonal pairs through the design of electronically activated sulfamate-containing cycloalkynes. Yun Hu, Jessica M. Roberts, Henry R. Kilgore, Amirah S. Mat Lani, Ronald T. Raines, and Jennifer M. Schomaker (2020). Journal of the American Chemical Society 142, 18826–18835. [PubMed] [PDF] [Supporting Information 1] [Supporting Information 2] [Synfacts] (Preprint DOI: 10.26434/chemrxiv.12543254.v1.)
  13. Optical imaging of collagen fiber damage to assess thermally injured human skin. Alexandra B. Schroeder, Aos Karim, Edgar Ocotl, Jenu V. Chacko, Aiping Liu, Jesús M. Dones, Ronald T. Raines, Angela L. F. Gibson, and Kevin W. Elicieri (2020). Wound Repair and Regeneration 28, 848–855. [PubMed] [PDF] [Supporting Information]
  14. Antimicrobial synergy of a ribonuclease and a peptide secreted by human cells. Chelcie H. Eller and Ronald T. Raines (2020). ACS Infectious Diseases 6, 3083–3088. [PubMed] [PDF]
  15. Palladium–protein oxidative addition complexes by amine-selective acylation. Heemal H. Dhanjee, Ivan Buslov, Ian W. Windsor, Ronald T. Raines, Bradley L. Penelute, and Stephen L. Buchwald (2020). Journal of the American Chemical Society 142, 21237–21242. [PubMed] [PDF] [Supporting Information]

Commentary

  1. Daniel S. Kemp (1936–2020): A pioneer of bioorganic chemistry. Paramjit S. Arora and Ronald T. Raines (2020). ACS Chemical Biology 15, 2620–2022. [PubMed] [PDF]

Preprints

  1. Stereoelectronic Effects Impact Glycan Recognition. Caitlin M. McMahon, Christine R. Isabella, Ian W. Windsor, Paul Kosma, R. T. Raines, and Laura Kiessling (2020). chemRxiv 11541927.v1.
  2. Triple, mutually orthogonal cycloadditions through the design of electronically activated SNO-OCTs. Yun Hu, Jessica M. Roberts, Henry R. Kilgore, Amirah Mat Lani, Ronald Raines, and Jennifer Sdhomaker (2020_ chemRxiv 12543254.v1.
  3. Boronic acid with high oxidative stability and utility in biological contexts. Brian J. Graham, Ian W. Windsor, Brian Gold, and Ronald T. Raines (2020). chemRxiv 13337399.v1.
2019

Publications—2019

Peer-Reviewed Journal Articles (Original Research)

  1. An n→π* interaction in the bound substrate of aspartic proteases replicates the oxyanion hole. Ian W. Windsor, Brian Gold, and Ronald T. Raines (2019). ACS Catalysis 9, 1464–1471. [PubMed] [PDF] [Supporting Information]
  2. Catalysis of hydrogen–deuterium exchange reactions by 4-substituted proline derivatives. Eddie L. Myers, Michael J. Palte, and Ronald T. Raines (2019). Journal of Organic Chemistry 84, 1247–1256. [PubMed] [PDF] [Supporting Information]
  3. Consequences of the N-glycosylation of human ribonuclease 1. Valerie T. Ressler and Ronald T. Raines (2019). Biochemistry 58, 987–996. [PubMed] [PDF] [Supporting Information]
  4. Esterification delivers a functional enzyme into a human cell. Valerie T. Ressler, Kalie A. Mix, and Ronald T. Raines (2019). ACS Chemical Biology 14, 599–602. [PubMed] [PDF] [Supporting Information]
  5. The collagen prolyl hydroxylases are bifunctional growth regulators in melanoma. Aithne Atkinson, Alexander Renziehausen, Hexiao Wang, Cristiana Lo Nigro, Laura Lattanzio, Marco Merlano, Bhavya Rao, Lynda Weir, Alan Evans, Peter Szlosarek, J. Geoffrey Pickering, Colin Fleming, Van Ren Sim, Su Li, James D. Vasta, Ronald T. Raines, Alastair Thompson, Charlotte Proby, Tim Crook, and Nelofer Syed (2019). Journal of Investigative Dermatology 139, 1118–1126. [PubMed] [PDF] [Supporting Information]
  6. Hyperconjugative π→σ*CF interactions stabilize the enol form of perfluorinated cyclic keto–enol systems. Brian J. Levandowski, Ronald T. Raines, and K. N. Houk (2019). Journal of Organic Chemistry 84, 6432–6436. [PubMed] [PDF] [Supporting Information]
  7. Efficient metal-free conversion of glucose to 5-hydroxymethylfurfural using a boronic acid. Brian J. Graham and Ronald T. Raines (2019). Biomass Conversion and Biorefinery 9, 471–477. [PDF] [Supporting Information]
  8. Terbium(III) luminescence-based assay for esterase activity. Kenton J. Hetrick, Miguel A. Aguilar Ramos, and Ronald T. Raines (2019). Analytical Chemistry 91, 8615–8621. [PubMed] [PDF] [Supporting Information]
  9. Phenotype of ribonuclease 1 deficiency in mice. Emily R. Garnett, Jo E. Lomax, Bassem Mohammed, David Gailani, John P. Sheehan, and Ronald T. Raines (2019). RNA 25, 921–934. [PubMed] [PDF] [Supporting Information]
  10. Circular zymogens of human ribonuclease 1. Ian W. Windsor, Crystal J. Graff, and Ronald T. Raines (2019). Protein Science 28, 1713–1719. [PubMed] [PDF] [Supporting Information]
  11. Angiogenin activates the astrocytic Nrf2/antioxidant-response element pathway and thereby protects murine neurons form oxidative stress. Trish T. Hoang, Delinda A. Johnson, Ronald T. Raines, and Jeffrey A. Johnson (2019). Journal of Biological Chemistry 294, 15095–15103. [PubMed] [PDF]
  12. Hyperconjugative antiaromaticity activates 4H-pyrazoles as inverse-electron demand Diels–Alder dienes. Brian J. Levandowski, Nile S. Abularrage, K. N. Houk, and Ronald T. Raines (2019). Organic Letters 21, 8492–8495. [PubMed] [PDF] [Supporting Information]
  13. Nucleoside tetra- and pentaphosphates prepared using a tetraphosphorylation reagent as inhibitors of ribonuclease A. Scott M. Shepard, Ian W. Windsor, Ronald T. Raines, and Christopher C. Cummins (2019). Journal of the American Chemical Society 141, 1840–18404. [PubMed] [PDF] [Supporting Information]
  14. Optimization of interstrand interactions enables burn detection with a collagen-mimetic peptide. Jesús M. Dones, I. Caglar Tanrikulu, Jenu V. Chacko, Alexandra B. Schroeder, Trish T. Hoang, Angela L. F. Gibson, Kevin W. Eliceiri, and Ronald T. Raines (2019). Organic & Biomolecular Chemistry 17, 9906–9912. [PubMed] [PDF] [Supporting Information]

Peer-Reviewed Journal Article (Review)

  1. Secondary forces in protein folding. Robert W. Newberry and Ronald T. Raines (2019). ACS Chemical Biology 14, 1677–1686. [PubMed] [PDF]

Commentary

  1. Delivery of proteins and nucleic acids: Achievements and challenges. Theresa M. Reineke, Ronald T. Raines, and Vincent M. Rotello (2019). Bioconjugate Chemistry 30, 261–262. [PubMed] [PDF]

Abstract

  1. Monofunctionalization with dextrans endows cell-penetrative properties to proteins. Henry R. Kilgore, Valerie T. Ressler, and Ronald T. Raines (2019). FASEB Journal 33, Supplement 1, 634.7.
2018

Publications—2018

Peer-Reviewed Journal Articles (Original Research)

  1. Site-specific antibody functionalization using tetrazine–styrene cycloaddition. Benjamin J. Umlauf, Kalie A. Mix, Ronald T. Raines, and Eric S. Shusta (2018). Bioconjugate Chemistry 29, 1605–1613. [PubMed] [PDF] [Supporting Information]
  2. COVER ARTICLE Cytosolic uptake of large monofunctionalized dextrans. Wen Chyan, Henry R. Kilgore, and Ronald T. Raines (2018). Bioconjugate Chemistry 29, 1942–1949. [PubMed] [PDF] [Supporting Information]
  3. A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding with HIV-1 protease. Ian W. Windsor and Ronald T. Raines (2018). Acts Crystallographica D74, 690–694. [PubMed] [PDF]
  4. Human angiogenin is a potent cytotoxin in the absence of ribonuclease inhibitor. Sidney P. Thomas, Trish T. Hoang, Valerie T. Ressler, and Ronald T. Raines (2018). RNA 24, 1018–1027. [PubMed] [PDF] [Supporting Information]
  5. A pendant peptide endows a sunscreen with water-resistance. Aubrey J. Ellison and Ronald T. Raines (2018). Organic & Biomolecular Chemistry 16, 7139–7142. [PubMed] [PDF] [Supporting Information]
  6. Sub-picomolar inhibition of HIV-1 protease with a boronic acid. Ian W. Windsor, Michael J. Palte, John C. Lukesh, III, Brian Gold, Katrina T. Forest, and Ronald T. Raines (2018). Journal of the American Chemical Society 140, 14015–14018. [PubMed] [PDF] [Supporting Information]
  7. A human ribonuclease variant and ERK-pathway inhibitors exhibit highly synergistic toxicity of cancer cells. Trish T. Hoang, I. Caglar Tanrikulu, Quinn A. Vatland, Trieu M. Hoang, and Ronald T. Raines (2018). Molecular Cancer Therapeutics 17, 2622–2632. [PubMed] [PDF] [Supporting Information] [Highlight]
  8. n→π* Interactions modulate the properties of cysteine residues and disulfide bonds in proteins. Henry R. Kilgore and Ronald T. Raines (2018). Journal of the American Chemical Society 140, 17606–17611. [PubMed] [PDF] [Supporting Information]

Peer-Reviewed Journal Articles (Reviews)

  1. Enzyme-activated fluorogenic probes for live-cell and in vivo imaging. Wen Chyan and Ronald T. Raines (2018). ACS Chemical Biology 13, 1810–1823. [PubMed] [PDF]
  2. Collagen prolyl 4-hydroxylase as a therapeutic target. James D. Vasta and Ronald T. Raines (2018). Journal of Medicinal Chemistry 61, 10403–10411. [PubMed] [PDF]

Abstract

  1. Anaerobic 4-hydroxyproline metabolism by a widespread microbial glycol radical enzyme. Yolanda Y. Huang, Lindsey Backman, Brian Gold, Ronald T. Raines, Catherine L. Drennan, Emily P. Balskus (2018). FASEB Journal 32, Supplement S, 534.16.
2017

Publications—2017

Peer-Reviewed Journal Articles (Original Research)

  1. Prolyl 4-hydroxylase: Substrate isosteres in which an (E)- or (Z)-alkene replaces the prolyl peptide bond. James D. Vasta, Amit Choudhary, Katrina H. Jensen, Nicholas A. McGrath, and Ronald T. Raines (2017). Biochemistry 56, 219–227. [PubMed] [PDF] [Supporting Information]
  2. Molecular basis for the autonomous promotion of cell proliferation by angiogenin. Trish T. Hoang and Ronald T. Raines (2017). Nucleic Acids Research 45, 818–831. [PubMed] [PDF] [Supporting Information]
  3. A boronic acid conjugate of angiogenin that shows ROS-responsive neuroprotective activity. Trish T. Hoang, Thomas P. Smith, and Ronald T. Raines (2017). Angewandte Chemie International Edition 56, 2619–2622. [PubMed] [PDF] [Supporting Information]
  4. Electronic and steric optimization of fluorogenic probes for biomolecular imaging. Wen Chyan, Henry R. Kilgore, Brian Gold, and Ronald T. Raines (2017). Journal of Organic Chemistry 82, 4297–4304. [PubMed] [PDF] [Supporting Information]
  5. Comparative functional analysis of ribonuclease 1 homologs: Molecular insights into evolving vertebrate physiology. Jo E. Lomax, Chelcie H. Eller, and Ronald T. Raines (2017). Biochemical Journal 474, 2219–2233. [PubMed] [PDF] [Supporting Information]
  6. Fine-tuning strain and electronic activation of strain-promoted 1,3-dipolar cycloadditions with endocyclic sulfamate in SNO-OCTs. Eileen G. Burke, Brian Gold, Trish T. Hoang, Ronald T. Raines, and Jennifer M. Schomaker (2017). Journal of the American Chemical Society 139, 8029–8037. [PubMed] [PDF] [Supporting Information 1] [Supporting Information 2]
  7. Stilbene boronic acids form a covalent bond with human transthyretin and inhibit its aggregation. Thomas P. Smith, Ian W. Windsor, Katrina T. Forest, and Ronald T. Raines (2017). Journal of Medicinal Chemistry 60, 7820–7834. [PubMed] [PDF] [Supporting Information]
  8. Cytosolic delivery of proteins by bioreversible esterification. Kalie A. Mix, Jo E. Lomax, and Ronald T. Raines (2017). Journal of the American Chemical Society 139, 14396–14398. [PubMed] [PDF] [Supporting Information]

Invited Journal Article

  1. 1-[3-(Diphenylphosphino)-propanoyl]-2,5-pyrrolidindione. Indrajeet Sharma, Lindsey R. Orgren, and Ronald T. Raines (2017). e-EROS Encyclopedia of Reagents for Organic Synthesis. [PDF]

Peer-Reviewed Journal Articles (Reviews)

  1. 4-Fluoroprolines: Conformational analysis and effects on the stability and folding of peptides and proteins. Robert W. Newberry and Ronald T. Raines (2017). Topics in Heterocyclic Chemistry 48, 1–26. [PubMed] [PDF]
  2. The n→π* interaction. Robert W. Newberry and Ronald T. Raines (2017). Accounts of Chemical Research 50, 1838–1846. [PubMed] [PDF]

Commentary

  1. COVER ARTICLE Peptides on the rise. Ronald T. Raines and Helma Wennemers (2017). Accounts of Chemical Research 50, 2419. [PubMed] [PDF]

Abstracts

  1. Successful treatment of bleomycin-induced lung fibrosis by a modified antioxidant. Rudolf K. Braun, Ronald T. Raines, John C. Lukesh, Francis Tsao, Marlowe Eldridge, and Keith C. Meyer (2017). Journal of Respiratory and Critical Care Medicine 195A6355.
  2. Loss of RNase1 produces coagulation abnormalities in mice. Emily R. Garnett and Ronald T. Raines (2017).
    FASEB Journal 31, Supplement 1, 674.12.
  3. Stereoelectronically stabilized fluorogenic probes for esterase-activated biomolecule imaging. Henry R. Kilgore, Wen Chyan, Brian Gold, and Ronald T. Raines (2017). FASEB Journal 31, Supplement 1, 767.18.
2016

Publications—2016

Peer-Reviewed Journal Articles (Original Research)

  1. Crystal structure of N-(3-oxobutanoyl)-L-homoserine lactone. Robert W. Newberry and Ronald T. Raines (2016). Acta Crystallographica E72, 136–139. [PubMed] [PDF]
  2. Selective inhibition of collagen prolyl 4-hydroxylase in human cells. James D. Vasta, Kristen A. Andersen, Kathryn M. Deck, Christopher P. Nizzi, Richard S. Eisenstein, and Ronald T. Raines (2016). ACS Chemical Biology 11, 193–199. [PubMed] [PDF] [Supporting Information]
  3. Boronic acid for the traceless delivery of proteins into cells. Kristen A. Andersen, Thomas P. Smith, Jo E. Lomax, and Ronald T. Raines (2016). ACS Chemical Biology 11, 319–323. [PubMed] [PDF] [Supporting Information]
  4. 1,3-Dipolar cycloadditions of diazo compounds in the presence of azides. Matthew R. Aronoff, Brian Gold, and Ronald T. Raines (2016). Organic Letters 18, 1538–1541. [PubMed] [PDF] [Supporting Information]
  5. Rapid cycloaddition of a diazo compound with an unstrained dipolarophile. Matthew R. Aronoff, Brian Gold, and Ronald T. Raines (2016). Tetrahedron Letters 57 2347–2350. [PubMed] [PDF] [Supporting Information]
  6. Human collagen prolyl 4-hydroxylase is activated by ligands for its iron center. James D. Vasta and Ronald T. Raines (2016). Biochemistry 55, 3224–3233. [PubMed] [PDF] [Supporting Information]
  7. Replacing a single atom accelerates the folding of a protein and increases its thermostability. Ulrich Arnold and Ronald T. Raines (2016). Organic & Biomolecular Chemistry 14, 6780–6785. [PubMed] [PDF] [Supporting Information]
  8. Decreasing distortion energies without strain: Diazo-selective 1,3-dipolar cycloadditions. Brian Gold, Matthew R. Aronoff, and Ronald T. Raines (2016). Journal of Organic Chemistry 81, 5998–6006. [PubMed] [PDF] [Supporting Information]
  9. n→π* Interactions are competitive with hydrogen bonds. Robert W. Newberry, Samuel J. Orke, and Ronald T. Raines (2016). Organic Letters 18, 3614–361. [PubMed] [PDF] [Supporting Information]
  10. 1,3-Dipolar cycloaddition with diazo groups: Noncovalent interactions overwhelm strain. Brian Gold, Matthew R. Aronoff, and Ronald T. Raines (2016). Organic Letters 18, 4466–4469. [PubMed] [PDF] [Supporting Information]
  11. COVER ARTICLE Peptide tessellation yields micrometre-scale collagen triple helices. I. Caglar Tanrikulu, Audrey Forticaux, Song Jin, and Ronald T. Raines (2016). Nature Chemistry 8, 1008–1014. [PubMed] [PDF] [Supporting Information]
  12. A prevalent intraresidue hydrogen bond stabilizes proteins. Robert W. Newberry and Ronald T. Raines (2016). Nature Chemical Biology 12, 1084–1088. [PubMed] [PDF] [Supporting Information 1] [Supporting Information 2]
  13. PTENpred: A designer protein impact predictor for PTEN-related disorders. Sean B. Johnston and Ronald T. Raines (2016). Journal of Computational Biology 23, 969–975. [PubMed] [PDF] [Supporting Information] [Website]
  14. Knockout of the ribonuclease inhibitor gene leaves human cells vulnerable to secretory ribonucleases. Sydney P. Thomas, Eunji Kim, Jin-Soo Kim, and Ronald T. Raines (2016). Biochemistry 55, 6359–6362. [PubMed] [PDF] [Supporting Information]
  15. COVER ARTICLE Anchoring a cytoactive factor in a wound bed promotes healing. Sayani Chattopadhyay, Kathleen M. Gutherie, Leandro Teixeira, Christopher J. Murphy, Richard R. Dubielzig, Jonathan F. McAnulty, and Ronald T. Raines (2016). Journal of Tissue Engineering and Regenerative Medicine 10, 1012–1020. [PubMed] [PDF]

Peer-Reviewed Journal Article (Review)

  1. Diazo compounds: Versatile tools for chemical biology. Kalie A. Mix, Matthew R. Aronoff, and Ronald T. Raines (2016). ACS Chemical Biology 11, 3233–3244. [PubMed] [PDF]
2015

Publications—2015

Peer-Reviewed Journal Articles (Original Research)

  1. Diazo compounds for the bioreversible esterification of proteins. Nicholas A. McGrath, Kristen A. Andersen, Amy K. F. Davis, Jo E. Lomax, and Ronald T. Raines (2015). Chemical Science 6, 752–755. [PubMed] [PDF] [Supporting Information]
  2. ​Intrinsic site-selectivity of ubiquitin dimer formation. Kristen A. Andersen, Langdon J. Martin, Joel M. Prince, and Ronald T. Raines (2015) Protein Science 24, 182–189. [PubMed] [PDF] [Supporting Information]
  3. Catalysis by the tumor-suppressor enzymes PTEN and PTEN-L. Sean B. Johnston and Ronald T. Raines (2015). PLoS ONE 10, e01168098. [PubMed] [PDF]
  4. ​An evolved Mxe GyrA intein for enhanced production of fusion proteins. Carrie J. Marshall, Vanessa A. Grosskopf, Taylor J. Moehling, Benjamin J. Tillotson, Gregory J. Wiepz, Nicholas L. Abbott, Ronald T. Raines, and Eric V. Shusta (2015) ACS Chemical Biology 10, 527–538. [PubMed] [PDF] [Supporting Information]
  5. Conformational stability and catalytic activity of PTEN variants linked to cancers and autism spectrum disorders. Sean B. Johnston and Ronald T. Raines (2015). Biochemistry 54, 55–65. [PubMed] [PDF] [Supporting Information]
  6. Diazo groups endure metabolism and enable chemoselectivity in cellulo. Kristen A. Andersen, Matthew R. Aronoff, Nicholas A. McGrath, and Ronald T. Raines (2015). Journal of the American Chemical Society 137, 2412–2415. [PubMed] [PDF] [Supporting Information]
  7. ​Assignments of RNase A by ADAPT-NMR and Enhancer. Marco Tonelli, Chelcie H. Eller, Kiran K. Singarapu, Woonghee Lee, Arash Bahrami, William M. Westler, Ronald T. Raines, and John L. Markley (2015). Biomolecular NMR Assignments 9, 81–88. [PubMed] [PDF]
  8. 4-Ketoproline: An electrophilic proline analog for bioconjugation. Amit Choudhary, Kimberli J. Kamer, Matthew D. Shoulders, and Ronald T. Raines (2015) Peptide Science 104, 110–115. [PubMed] [PDF] [Supporting Information]
  9. Separation of lignin from corn stover hydrolysate with quantitative recovery of ionic liquid. Kaylee A. Underkofler, Rodrigo E. Teixeira, Stephen A. Pietsch, Kurtis G. Knapp, and Ronald T. Raines (2015) ACS Sustainable Chemistry & Engineering 3, 606–613. [PubMed] [PDF]
  10. Optimized diazo scaffold for protein esterification. Kalie A. Mix and Ronald T. Raines (2015). Organic Letters 17, 2359–2361. [PubMed] [PDF] [Supporting Information]
  11. Thioamides in the collagen triple helix. Robert W. Newberry, Brett VanVeller, and Ronald T. Raines (2015). Chemical Communications 51, 9624–9627. [PubMed] [PDF] [Supporting Information]
  12. Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates. James D. Vasta and Ronald T. Raines (2015). Bioorganic & Medicinal Chemistry 23, 3081–3090. [PubMed] [PDF] [Supporting Information]
  13. Human cancer antigen Globo H is a cell-surface ligand for human ribonuclease 1. Chelcie H. Eller, Tzu-Yuan Chao, Kiran K. Singarapu, Ouathek Ouerfelli, Guangbin Yang, John L. Markley, Samuel J. Danishefsky, and Ronald T. Raines (2015). ACS Central Science 1, 181–190. [PubMed] [PDF] [Supporting Information]
  14. Fluorogenic assay for inhibitors of HIV-1 protease with sub-picomolar affinity. Ian W. Windsor and Ronald T. Raines (2015). Scientific Reports 5, 11286. [PubMed] [PDF]
  15. α/β-Peptide foldamers targeting intracellular protein–protein interactions with activity in living cells. James W. Checco, Erinna F. Lee, Marco Evangelista, Nerida Sleebs, Kelly Rodgers, Anne Pettikiriarachchi, Nadia Kershaw, Geoffrey A. Eddinger, David G. Belair, Julia L. Wilson, Chelcie H. Eller, Ronald T. Raines, William L. Murphy, Brian J. Smith, Samuel H. Gellman, and W. Douglas Fairlie (2015). Journal of the American Chemical Society 137, 11365–11375. [PubMed] [PDF] [Supporting Information]
  16. Coevolution of RtcB and Archease created a multiple-turnover RNA ligase. Kevin K. Desai, Amanda L. Beltrame, and Ronald T. Raines (2015). RNA 21, 1866–1872. [PubMed] [PDF]
  17. Target selection by natural and redesigned PUF proteins. Douglas F. Porter, Yvonne Y. Koh, Brett VanVeller, Ronald T. Raines, and Marvin Wickens (2015). Proceedings of the National Academy of Sciences, U.S.A. 112, 15868–15873. [PubMed] [PDF] [Supporting Information]
  18. Convenient synthesis of collagen-related peptides for segment condensation. Aubrey J. Ellison, Brett VanVeller, and Ronald T. Raines (2015). Peptide Science 104, 674–681. [PubMed] [PDF] [Supporting Information]

Peer-Reviewed Journal Article (Review)

  1. Biomass to furanics: Renewable routes to chemicals and fuels. Benjamin R. Caes, Rodrigo E. Teixeira, Kurtis G. Knapp, and Ronald T. Raines (2015). ACS Sustainable Chemistry & Engineering 3, 2591–2605. [PDF]

Invited Journal Articles

  1. Creating site-specific isopeptide linkages between proteins with the traceless Staudinger ligation. Kristen A. Andersen and Ronald T. Raines (2015). Methods in Molecular Biology 1248, 55–65. [PubMed] [PDF]
  2. Fluorescence polarization assay to quantify protein–protein interactions—an update. Ronald T. Raines (2015). Methods in Molecular Biology 1278, 323–327. [PubMed] [PDF]

Conference Proceeding

  1. The main-chain oxygen: Unappreciated effects on peptide and protein structure. Robert W. Newberry and Ronald T. Raines (2015). In Enabling Peptide Research from Basic Science to Drug Discovery: Proceedings of the 24th American Peptide Symposium (Ved Srivastava, Andrei Yudin, and Michal Lebl, Eds.), pp. 20–21, Prompt Scientific Publishing, San Diego, CA. [PDF]
2014

Publications—2014

Peer-Reviewed Journal Articles (Original Research)

  1. Effects of a second-generation human anti-ErbB2 immunoRNase on trastuzumab-resistant tumors and cardiac cells. Chiara D’Avino, Rolando Paciello, Gennaro Riccio, Melina Coppola, Paolo Laccetti, Nicola Maurea, Ronald T. Raines, and Claudia De Lorenzo (2014). Protein Engineering, Design & Selection 27, 83–88. [PubMed] [PDF]
  2. Signatures of n→π* interactions in proteins. Robert W. Newberry, Gail J. Bartlett, Brett VanVeller, Derek N. Woolfson, and Ronald T. Raines (2014). Protein Science 23, 284–288. [PubMed] [PDF] [Supporting Information]
  3. A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation. Kevin K. Desai, Chin L. Cheng, Craig A. Bingman, George N. Phillips, Jr., and Ronald T. Raines (2014). Nucleic Acids Research 42, 3931–3942. [PubMed[PDF] [Supporting Information]
  4. COVER ARTICLE Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Lauren M. Zasadil, Kristen A. Andersen, Dabin Yeum, Gabrielle B. Rocque, Lee G. Wilke, Amye J. Tevaarwerk, Ronald T. Raines, Mark E. Burkard, and Beth A. Weaver (2014). Science Translational Medicine 6, 229ra43. [PubMed] [PDF] [Supporting Information]
  5. A key n→π* interaction in N-acyl homoserine lactones. Robert W. Newberry and Ronald T. Raines (2014). ACS Chemical Biology 9, 880–883. [PubMed] [PDF] [Supporting Information]
  6. n→π* Interactions engender chirality in carbonyl groups. Amit Choudhary, Robert W. Newberry, and Ronald T. Raines (2014). Organic Letters 16, 3421–3423. [PubMed] [PDF] [Supporting Information]
  7. Pyrazine-derived disulfide-reducing agent for chemical biology. John C. Lukesh, III, Kelly K. Wallin, and Ronald T. Raines (2014). Chemical Communications 50, 9591–9594. [PubMed] [PDF] [Supporting Information]
  8. Functional evolution of ribonuclease inhibitor: Insights from birds and reptiles. Jo E. Lomax, Christopher M. Bianchetti, Aram Chang, George N. Phillips, Jr., Brian G. Fox, and Ronald T. Raines (2014). Journal of Molecular Biology 426, 3041–3056. [PubMed] [PDF] [Supporting Information]
  9. Bovine brain ribonuclease is the functional homolog of human ribonuclease 1. Chelcie H. Eller, Jo E. Lomax, and Ronald T. Raines (2014). Journal of Biological Chemistry 289, 25996–26006. [PubMed] [PDF]
  10. Structure of RNA-phosphate cyclase bound to substrate RNA. Kevin K. Desai and Ronald T. Raines (2014). RNA 20, 1560–1566. [PubMed] [PDF] [Supporting Information]
  11. Affinity of monoclonal antibodies for Globo-series glycans. Chelcie H. Eller, Guangbin Yang, Ouathek Ouerfelli, and Ronald T. Raines (2014). Carbohydrate Research 397, 1–6. [PubMed] [PDF] [Supporting Information]
  12. Optimal interstrand bridges for collagen-like biomaterials. I. Caglar Tanrikulu and Ronald T. Raines (2014). Journal of the American Chemical Society 136, 13490–13493. [PubMed] [PDF] [Supporting Information]
  13. Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase. John C. Lukesh, III, Kristen A. Andersen, Kelly K. Wallin, and Ronald T. Raines (2014). Organic & Biomolecular Chemistry 12, 8598–8602. [PubMed] [PDF] [Supporting Information]

Peer-Reviewed Journal Articles (Reviews)

  1. Bright building blocks for chemical biology. Luke D. Lavis and Ronald T. Raines (2014). ACS Chemical Biology 9, 855–866. [PubMed] [PDF]
  2. Collagen-based biomaterials for wound healing. Sayani Chattopadhyay and Ronald T. Raines (2014). Biopolymers 101, 821–833. [PubMed] [PDF]

Abstracts

  1. Protection and detection of boronic acids. Matthew Aronoff, Brett VanVeller, and Ronald T. Raines (2014). Abstracts of Papers of the American Chemical Society 247, Organic Chemistry 662.
  2. Selective and bioavailable inhibitors of collagen prolyl 4-hydroxylase. James D. Vasta, Kristen A. Andersen, and Ronald T. Raines (2014). Abstracts of Papers of the American Chemical Society 248, Biological Chemistry 182.
  3. Convergent semisynthetic route to authentic ubiquitin chains. Kristen A. Andersen and Ronald T. Raines (2014). Abstracts of Papers of the American Chemical Society 248, Biological Chemistry 203.
  4. Bovine brain ribonuclease is the functional homolog of human ribonuclease 1. Chelcie H. Eller, Jo E. Lomax, and Ronald T. Raines (2014). Protein Science 23, Supplement 1, 102–103.
  5. n→π* Interactions in protein structure and folding. Robert W. Newberry and Ronald T. Raines (2014). Protein Science 23, Supplement 1, 238.
2013

Publications—2013

Peer-Reviewed Journal Articles (Original Research)

  1. Organocatalytic conversion of cellulose into a platform chemical. Benjamin R. Caes, Michael J. Palte, and Ronald T. Raines (2013). Chemical Science 4, 196–199. PubMed [PDF] [Supporting Information]
  2. Fluorogenic label to quantify the cytosolic delivery of macromolecules. Tzu-Yuan Chao and Ronald T. Raines (2013). Molecular BioSystems 9, 339–342. [PubMed] [PDF]
  3. A novel fully human antitumor immunoRNase resistant to the RNase inhibitor. Gennaro Riccio, Chiara D’Avino, Ronald T. Raines, and Claudia De Lorenzo (2013). Protein Engineering, Design & Selection 26, 243–248. [PubMed] [PDF]
  4. Protein prosthesis: β-Peptides as reverse-turn surrogates. Ulrich Arnold, Bayard R. Huck, Samuel H. Gellman, and Ronald T. Raines (2013). Protein Science 22, 274–279. [PubMed] [PDF] [ Supporting Information]
  5. Intimate interactions with carbonyl groups: Dipole–dipole or nπ*? Kimberli J. Kamer, Amit Choudhary, and Ronald T. Raines (2013). Journal of Organic Chemistry 78, 2099–2103. [PubMed] [PDF] [Supporting Information]
  6. Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation. Kevin K. Desai, Craig A. Bingman, George N. Phillips, Jr., and Ronald T. Raines (2013). Biochemistry 52, 2518–2525. [PubMed] [PDF] [Supporting Information]
  7. Fluorogenic probe for constitutive cellular endocytosis. Michael N. Levine, Trish T. Hoang, and Ronald T. Raines (2013). Chemistry & Biology 20, 614–618. [PDF] [Supporting Information]
  8. Pyramidalization of a carbonyl C atom in (2S)-N-(selenoacteyl)proline methyl ester. Ilia A. Guzei, Amit Choudhary, and Ronald T. Raines (2013). Acta Crystallographica E69, o805–o806. [PubMed] [PDF]
  9. n→π* Interactions of amides and thioamides: Implications for protein stability. Robert W. Newberry, Brett VanVeller, and Ronald T. Raines (2013). Journal of the American Chemical Society 135, 7843–7846. [PubMed]
  10. Bioavailable affinity label for collagen prolyl 4-hydroxylase. James D. Vasta, Joshua J. Higgin, Elizabeth A. Kersteen, and Ronald T. Raines (2013). Bioorganic & Medicinal Chemistry 21, 3597–3601. [PubMed]
  11. Human ribonuclease with a pendant poly(ethylene glycol) inhibits tumor growth in mice. Thomas J. Rutkoski, John A. Kink, Laura E. Strong, and Ronald T. Raines (2013). Translational Oncology 6, 392–397. [PubMed] [PDF]
  12. n→π* Interactions in poly(lactic acid) suggest a role in protein folding. Robert W. Newberry and Ronald T. Raines (2013). Chemical Communications 49, 7699–7701. [PubMed] [PDF]
  13. An n→π* interaction reduces the electrophilicity of the acceptor carbonyl group. Amit Choudhary, Charles G. Fry, Kimberli J. Kamer, and Ronald T. Raines (2013). Chemical Communications 49, 8166–8168. [PubMed] [PDF] [Supporting Information]
  14. Contribution of electrostatics to the binding of pancreatic-type ribonucleases to membranes. Nadia K. Sundlass, Chelcie H. Eller, Qiang Cui, and Ronald T. Raines (2013). Biochemistry 52, 6304–6312. [PubMed] [PDF]
  15. Facile chemical functionalization of proteins through intein-linked yeast display. Carrie J. Marshall, Nitin Agarwal, Jeet Kalia, Vanessa A. Grosskopf, Nicholas A. McGrath, Ronald T. Raines, and Eric V. Shusta (2013). Bioconjugate Chemistry 24, 1634–1644. [PubMed] [PDF] [Supporting Information]
  16. Conversion of azides into diazo compounds in water. Ho-Hsuan Chou and Ronald T. Raines (2013). Journal of the American Chemical Society 135, 14936–14939. [PubMed] [PDF] [Supporting Information]
  17. A divalent protecting group for benzoxaboroles. Brett VanVeller, Matthew R. Aronoff, and Ronald T. Raines (2013). RSC Advances 3, 21331–21333. [PubMed] [PDF] [Supporting Information]
  18. Simulated moving bed chromatography: Separation and recovery of sugars and ionic liquid from biomass hydrolysates. Benjamin R. Caes, Thomas R. Van Oosbree, Fachuang Lu, John Ralph, Christos T. Maravelias, and Ronald T. Raines (2013). ChemSusChem 6, 2083–2089. [PubMed] [PDF] [Supporting Information]
  19. COVER ARTICLE Thiols and selenols as electron-relay catalysts for disulfide-bond reduction. John C. Lukesh, III, Brett VanVeller, and Ronald T. Raines (2013). Angewandte Chemie International Edition 52, 12901–12904. [PubMed] [PDF] [Supporting Information]
  20. Detection of boronic acids through excited-state intramolecular proton-transfer fluorescence. Matthew R. Aronoff, Brett VanVeller, and Ronald T. Raines (2013). Organic Letters 15, 5382–5385. [PubMed] [PDF] [Supporting Information]
  21. Interplay of hydrogen bonds and nπ* interactions in proteins. Gail J. Bartlett, Robert W. Newberry, Brett VanVeller, Ronald T. Raines, and Derek N. Woolfson (2013). Journal of the American Chemical Society 135, 18682–18688. [PubMed] [PDF] [Supporting Information]

Conference Proceedings

  1. Enzymes as chemotherapeutic agents. Ronald T. Raines (2013). In Chembiomolecular Science: At the Frontier of Chemistry and Biology. Proceedings of the Uehara Memorial Foundation Symposium 2011 (Masakatsu Shibasaki, Masamitsu Iino, and Hiroyuki Osada, Eds.), pp. 281–291, Springer Japan, Tokyo, Japan. [PDF]
  2. n→π* Interactions in helices. Ronald T. Raines (2013). In Peptides Across the Pacific: The Proceedings of the 23rd American Peptide Symposium and the 6th International Peptide Symposium (Michal Lebl, Ed.), pp. 28–29, Prompt Scientific Publishing, San Diego, CA. [PDF]

Abstracts

  1. RNases: Approaching RNA as a target for cancer therapy. Laura E. Strong, John Kink, Baigen Mei, Mark Shahan and Ronald T. Raines (2013). Cancer Research 73(8), Supplement 1, 4405.
  2. n→π* Interactions in peptides and proteins. Ronald T. Raines (2013). Biopolymers 100(3), 232.
  3. Development of a yeast surface display platform for site-specific protein modifications. Carrie Marshall, Nitin Agarwal, Jeet Kalia, Nicholas A. McGrath, Ronald T. Raines, and Eric V. Shusta (2013). Abstracts of Papers of the American Chemical Society 245, Biotechnology, 417.
  4. Modulation of collagen stability with fluoro groups. Ronald T. Raines (2013). Abstracts of Papers of the American Chemical Society 245, Fluorine Chemistry, 24.
  5. n→π* Interactions in proteins and small molecules. Ronald T. Raines (2013). Abstracts of Papers of the American Chemical Society 245, Medicinal Chemistry, 6.
  6. Diazo compounds as highly tunable 1,3-dipoles for cycloaddition reactions with cyclooctynes. Nicholas A. McGrath and Ronald T. Raines (2013). Abstracts of Papers of the American Chemical Society 245, Organic Chemistry, 221.
  7. Construction of a potent, versatile disulfide-reducing agent from aspartic acid. John C. Lukesh, Michael J. Palte, and Ronald T. Raines (2013). Abstracts of Papers of the American Chemical Society 245, Organic Chemistry, 222.
  8. Longer, stronger synthetic collagens for nanotechnology and biomedicine. Ronald T. Raines (2013). Abstracts of Papers of the American Chemical Society 245, Organic Chemistry, 763.
2012

Publications—2012

Peer-Reviewed Journal Articles (Original Research)

  1. A conserved interaction with the chromophore of fluorescent proteins. Amit Choudhary, Kimberli J. Kamer, and Ronald T. Raines (2012). Protein Science 21, 171–177. [PubMed] [PDF] [Supporting Information]
  2. tRNA Ligase catalyzes the GTP-dependent ligation of RNA with 3′-phosphate and 5′-hydroxyl termini. Kevin K. Desai and Ronald T. Raines (2012). Biochemistry 51, 1333–1335. [PubMed] [PDF] [Supporting Information]
  3. Boronate-mediated biologic delivery. Gregory A. Ellis, Michael J. Palte, and Ronald T. Raines (2012). Journal of the American Chemical Society 134, 3631–3634. [PubMed] [PDF] [Supporting Information]
  4. A potent, versatile disulfide-reducing agent from aspartic acid. John C. Lukesh, III, Michael J. Palte, and Ronald T. Raines (2012). Journal of the American Chemical Society 134, 4057–4059. [PubMed] [PDF] [Supporting Information]
  5. Interaction of nucleic acids with the glycocalyx. Michael J. Palte and Ronald T. Raines (2012). Journal of the American Chemical Society 134, 6218–6223. [PubMed] [PDF] [Supporting Information]
  6. Ribonuclease-activated cancer prodrug. Gregory A. Ellis, Nicholas A. McGrath, Michael J. Palte, and Ronald T. Raines (2012). ACS Medicinal Chemistry Letters 3, 268–272. [PubMed] [PDF] [Supporting Information]
  7. Synthesis of 5-fluoro- and 5-hydroxymethanoprolines via lithiation of N-BLOC-methanopyrrolidines. Constrained Cγ-exo and Cγ-endo Flp and Hyp conformer mimics. Grant R. Krow, Matthew D. Shoulders, Ram Edupuganti, Deepa Gandla, Fang Yu, Philip E. Sonnet, Matthew Sender, Amit Choudhary, Charles DeBrosse, Charles W. Ross, III, Patrick Carroll, and Ronald T. Raines (2012). Journal of Organic Chemistry 77, 5331–5344. [PubMed] [PDF] [Supporting Information
  8. Conversion of biomass to sugars via ionic liquid hydrolysis: Process synthesis and economic evaluation. S. Murat Sen, Joseph B. Binder, Ronald T. Raines, and Christos T. Maravelias (2012). Biofuels, Bioproducts & Biorefining 6, 444–452. [PDF]
  9. Peptides that anneal to natural collagen in vitro and ex vivo. Sayani Chattopadhyay, Christopher J. Murphy, Jonathan F. McAnulty, and Ronald T. Raines (2012). Organic & Biomolecular Chemistry 10, 5892–5897. [PubMed] [PDF]
  10. COVER ARTICLE Ribonucleoside 3′-phosphates as pro-moieties for an orally administrated drug. Michael J. Palte, Amy K. F. Davis, Nicholas A. McGrath, and Ronald T. Raines (2012). ChemMedChem 7, 1361–1364. [PubMed] [PDF] [Supporting Information]
  11. Diazo-compounds as highly tunable reactants in 1,3-dipolar cycloaddition reactions with cycloalkynes. Nicholas A. McGrath and Ronald T. Raines (2012). Chemical Science 3, 3237–3240. [PubMed] [PDF] [Supporting Information]

Peer-Reviewed Journal Article (Reviews)

  1. Trimethyl lock: A trigger for molecular release in chemistry, biology, and pharmacology. Michael N. Levine and Ronald T. Raines (2012). Chemical Science 3, 2412–2420. [PubMed] [PDF]

Invited Journal Article

  1. Rational design and evaluation of mammalian ribonuclease cytotoxins. Jo E. Lomax, Chelcie H. Eller, and Ronald T. Raines (2012). Methods in Enzymology 502, 273–290. [PubMed] [PDF]

Book Chapter

  1. Knowles, Jeremy Randall (1935–2008). Ronald T. Raines (2012). In Oxford Dictionary of National Biography (Lawrence Goldman, Ed.), article 99981, Oxford University Press, Oxford, UK. [PDF]

Abstracts

  1. Efficacy of ribonuclease QBI-139 in combination with standard of care therapies. Laura E. Strong, John A. Kink, Daniel Pensinger, Baigen Mei, Mark Shahan, and Ronald T. Raines (2012). Cancer Research 72(8), Supplement 1, 1838.
  2. First-in-human phase I clinical trial of QBI-139, a human ribonuclease variant, in solid tumors. Laura E. Strong, John A. Kink, Baigen Mei, Mark N. Shahan, and Ronald T. Raines (2012). Journal of Clinical Oncology 30 (Supplement), TPS3113.
  3. Organocatalytic conversion of cellulose to furans for fuels and chemicals. Benjamin R. Caes, Michael J. Palte, and Ronald T. Raines (2012). Abstracts of Papers of the American Chemical Society 243, Cellulose, 70.
  4. Interaction of nucleic acids with the glycocalyx. Michael J. Palte and Ronald T. Raines (2012). Abstracts of Papers of the American Chemical Society 243, Medicinal Chemistry, 439.
  5. Electronic effects on protein structure. Ronald T. Raines (2012). Abstracts of Papers of the American Chemical Society 243, Organic Chemistry, 1.
  6. Electronic effects within the protein backbone. Ronald T. Raines (2012). Abstracts of Papers of the American Chemical Society 244, Organic Chemistry, 66.
2011

Publications—2011

Peer-Reviewed Journal Articles (Research)

  1. Ribonuclease S redux. Rex W. Watkins, Ulrich Arnold, and Ronald T. Raines (2011). Chemical Communications 47, 973–975. [PubMed] [ [PDF] [Supporting Information]
  2. Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of bovine pancreatic ribonuclease. Nethaji Thiyagarajan, Bryan D. Smith, Ronald T. Raines, and K. Ravi Acharya (2011). FEBS Journal 278, 541–549. [PubMed] [PDF] [Supporting Information]
  3. Disruption and formation of surface salt bridges are coupled to DNA binding by integration host factor (IHF): A computational analysis. Liang Ma, Nadia K. Sundlass, Ronald T. Raines, and Qiang Cui (2011). Biochemistry 50, 266–275. [PubMed] [PDF]
  4. Synthesis and utility of fluorogenic acetoxymethyl ethers. Luke D. Lavis, Tzu-Yuan Chao, and Ronald T. Raines (2011). Chemical Science 2, 521–530. [PubMed] [PDF] [Supporting Information]
  5. Conversion of fructose into 5-(hydroxymethyl)furfural in sulfolane. Benjamin R. Caes and Ronald T. Raines (2011). ChemSusChem 4, 353–356. [PubMed] [PDF] [Supporting Information]
  6. Tunable, post-translational hydroxylation of collagen domains in Escherichia coli. Daniel M. Pinkus, Sheng Ding, Ronald T. Raines, and Annelise E. Barron (2011). ACS Chemical Biology 6, 320–324. [PubMed] [PDF] [Supporting Information]
  7. Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer. Gregory A. Ellis, Megan L. Hornung, and Ronald T. Raines (2011). Bioorganic & Medicinal Chemistry Letters 21, 2756–2758. [PubMed] [PDF] [Supporting Information]
  8. Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides. Amit Choudhary, Khian Hong Pua, and Ronald T. Raines (2011). Amino Acids 41, 181–186. [PubMed] [PDF]
  9. Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines. Grant R. Krow, Matthew D. Shoulders, Ram Edupuganit, Deepa Gandla, Fang Yu, Matthew Sender, Philip E. Sonnet, Michael J. Zdilia, Charles DeBrosse, Kevin C. Cannon, Charles W. Ross, III, Amit Choudhary, and Ronald T. Raines (2011). Journal of Organic Chemistry 76, 3626–3634. [PubMed] [PDF] [Supporting Information]
  10. COVER ARTICLE Signature of n→π* interactions in α-helices. Amit Choudhary and Ronald T. Raines (2011). Protein Science 20, 1077–1081. [PubMed] [PDF] [Supporting Information]
  11. Interstrand dipole–dipole interactions can stabilize the collagen triple helix. Matthew D. Shoulders and Ronald T. Raines (2011). Journal of Biological Chemistry 286, 22905–22912. [PubMed] [PDF] [Supporting Information]
  12. Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity. Thomas J. Rutkoski, John A. Kink, Laura E. Strong, and Ronald T. Raines (2011). Cancer Biology & Therapy 12, 208–214. [PubMed] [PDF] [Supporting Information]
  13. Site-specific folate conjugation to a cytotoxic protein. Bryan D. Smith, Joshua J. Higgin, and Ronald T. Raines (2011). Bioorganic & Medicinal Chemistry Letters 21, 5029–5032. [PubMed] [PDF] [Supporting Information]
  14. Sensitive fluorogenic substrate for alkaline phosphatase. Michael N. Levine and Ronald T. Raines (2011). Analytical Biochemistry 418, 247–252. [PubMed] [PDF]
  15. Mechanism of ribonuclease A endocytosis: Analogies to cell-penetrating peptides. Tzu-Yuan Chao and Ronald T. Raines (2011). Biochemistry 50, 7835–7841. [PubMed] [PDF]
  16. An n→π* interaction in aspirin: Implications for structure and reactivity. Amit Choudhary, Kimberli J. Kamer, and Ronald T. Raines (2011). Journal of Organic Chemistry 76, 7933–7937.[PubMed] [PDF] [Supporting Information]
  17. Separable fluorous ionic liquids for the dissolution and saccharification of cellulose. Benjamin R. Caes, Joseph B. Binder, Jacqueline J. Blank, and Ronald T. Raines (2011). Green Chemistry 13, 2719–2722. [PDF]  [Supporting Information]
  18. Arginine residues are more effective than lysine residues in eliciting the cellular uptake of onconase. Nadia K. Sundlass and Ronald T. Raines (2011). Biochemistry 50, 10293–10299. [PubMed] [PDF]

Peer-Reviewed Journal Articles (Reviews)

  1. An evaluation of peptide-bond isosteres. Amit Choudhary and Ronald T. Raines (2011). ChemBioChem 12, 1801–1807. [PubMed] [PDF]
  2. Chemoselectivity in chemical biology: Acyl transfer reactions with sulfur and selenium. Nicholas A. McGrath and Ronald T. Raines (2011). Accounts of Chemical Research 44, 752–761. [PubMed] [PDF]
  3. Bovine pancreatic ribonuclease: Fifty years of the first enzymatic reaction mechanism. Claudi M. Cuchillo, M. Victòria Nogués, and Ronald T. Raines (2011). Biochemistry 50, 7835–7841. [PubMed] [PDF]

Abstracts

  1. Combinations of QBI-139, a clinical stage ribonuclease drug. Laura E. Strong, John A. Kink, Daniel Pensinger, Baigen Mei, Mark N. Shahan, and Ronald T. Raines (2011). Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research, 2573.
  2. A Phase I clinical trial of QBI-130, a human ribonuclease variant, in solid tumors. Laura E. Strong, John A. Kink, Baigen Mei, Mark N. Shahan, and Ronald T. Raines (2011). Journal of Clinical Oncology 29 (Supplement), TPS146.
  3. Chemical transformation of lignocellulosic biomass into furanics and sugars. Ronald T. Raines (2011). Abstracts of Papers of the American Chemical Society 241, Cellulose and Renewable Materials Chemistry, 261.
  4. Electronic effects on protein structure. Ronald T. Raines (2011). Abstracts of Papers of the American Chemical Society 241, Organic Chemistry, 376.
  5. Collagen mimetic peptides enable cutaneous wound assessment and expedite healing. Sayani Chattopadhyay, Kathy M. Guthrie, Leandro Teixeira, Lingyin Li, Laura L. Kiessling, Richard R. Dubeizig, Christopher J. Murphy, Jonathan F. McAnulty, and Ronald T. Raines (2011). Biopolymers 96(4), 427.
2010

Publications—2010

Peer-Reviewed Journal Articles (Original Research)

  1. Stereoelectronic and steric effects in side chains preorganize a protein main chain. Matthew D. Shoulders, Kenneth A. Satyshur, Katrina T. Forest, and Ronald T. Raines (2010). Proceedings of the National Academy of Sciences, U.S.A. 107, 559–564. [PubMed] [PDF] [Supporting Information]
  2. Fermentable sugars by chemical hydrolysis of biomass. Joseph B. Binder and Ronald T. Raines (2010). Proceedings of the National Academy of Sciences, U.S.A. 107, 4516–4521. [PubMed] [PDF] [Supporting Information]
  3. n→π* Interaction and n)(π Pauli repulsion are antagonistic for protein stability. Charles E. Jakobsche, Amit Choudhary, Scott J. Miller, and Ronald T. Raines (2010). Journal of the American Chemical Society 132, 6651–6653. [PubMed] [PDF] [Supporting Information]
  4. COVER ARTICLE Mechanistic insights on the conversion of sugars into 5-hydroxymethylfurfural. Joseph B. Binder, Anthony V. Cefali, Jacqueline J. Blank, and Ronald T. Raines (2010). Energy & Environmental Science 3, 765–771. [PDF]
  5. A stereoelectronic effect in prebiotic nucleotide synthesis. Amit Choudhary, Kimberli J. Kamer, Matthew W. Powner, John D. Sutherland, and Ronald T. Raines (2010). ACS Chemical Biology 5, 655–657. [PubMed] [PDF]
  6. n→π* Interactions in proteins. Gail J. Bartlett, Amit Choudhary, Ronald T. Raines, and Derek N. Woolfson (2010). Nature Chemical Biology 6, 615–620. [PubMed] [PDF] [Supporting Information]
  7. Modulation of an n→π* interaction with α-fluoro groups. Amit Choudhary, Charles G. Fry, and Ronald T. Raines (2010). ARKIVOC 251–262. [PDF]
  8. The aberrance of the 4S diastereomer of 4-hydroxyproline. Matthew D. Shoulders, Frank W. Kotch, Amit Choudhary, Ilia A. Guzei, and Ronald T. Raines (2010). Journal of the American Chemical Society 132, 10857–10865. [PubMed] [PDF] [Supporting Information]
  9. Antitumor activity of ribonuclease multimers created by site-specific covalent tethering. Thomas J. Rutkoski, John A. Kink, Laura E. Strong, Christine I. Schilling, and Ronald T. Raines (2010). Bioconjugate Chemistry 21, 1691–1702. [PubMed] [PDF] [Supporting Information]
  10. COVER ARTICLE Synthesis of furfural from xylose and xylan. Joseph B. Binder, Jacqueline J. Blank, Anthony V. Cefali, and Ronald T. Raines (2010). ChemSusChem 3, 1268–1272. [PubMed] [PDF]
  11. Oligomers of a 5-carboxy-methanopyrrolidine β-amino acid. A search for order. Grant R. Krow, Nian Liu, Matthew Sender, Guoliang Lin, Ryan Centafont, Philip E. Sonnet, Charles DeBrosse, Charles W. Ross, III, Patrick J. Carroll, Matthew D. Shoulders, and Ronald T. Raines (2010). Organic Letters 12, 5438–5441. [PubMed] [PDF] [Supporting Information]
  12. Cellular uptake of ribonuclease A relies on anionic glycans. Tzu-Yuan Chao, Luke D. Lavis, and Ronald T. Raines (2010). Biochemistry 49, 10666–10673. [PubMed] [PDF]

Peer-Reviewed Journal Articles (Reviews)

  1. Advances in bioconjugation. Jeet Kalia and Ronald T. Raines (2010). Current Organic Chemistry 14, 138–147.  [PubMed] [PDF]
  2. Prolyl 4-hydroxylase. Kelly L. Gorres and Ronald T. Raines (2010). Critical Reviews in Biochemistry and Molecular Biology 45, 106–124. [PubMed] [PDF]

Conference Proceeding

  1. n→π* Interactions in the molecules of life. Amit Choudhary and Ronald T. Raines (2010). In Peptides 2010: Tales of Peptides. Proceedings of the 31st European Peptide Symposium (Michal Lebl, Morten Meldal, Knud J. Jensen, and Thomas Hoeg-Jensen, Eds.), pp. 2–3, Prompt Scientific Publishing, San Diego. [PDF]

Commentary

  1. Carpe diubiquitin. Langdon J. Martin and Ronald T. Raines (2010). Angewandte Chemie International Edition 49, 9042–9044. [PubMed] [PDF]

Abstracts

  1. QBI-139, a human RNase variant in a Phase I trial, works in combination. Laura E. Strong, John A. Kink, Baigen Mei, Mark N. Shahan, and Ronald T. Raines (2010). Proceedings of the 101st Annual Meeting of the American Association for Cancer Research, 5390.
  2. Relationship of QBI-139, a human ribonuclease variant, and RNA in cancer cells. Laura E. Strong, John A. Kink, Baigen Mei, Mark N. Shahan, D. Pensinger, and Ronald T. Raines (2010). Journal of Clinical Oncology 28 (Supplement), e13650.
  3. Use of a human ribonuclease variant, QBI-139, for the treatment of cancer. Laura E. Strong, John A. Kink, Baigen Mei, Mark N. Shahan, and Ronald T. Raines (2010). Journal of Clinical Oncology 28:15s (Supplement), TPS162.
  4. Ribonuclease: From model system to the clinic. Ronald T. Raines (2010). Abstracts of Papers of the American Chemical Society 240, Biological Chemistry, 133.
  5. Fermentable sugars by chemical hydrolysis of biomass in an ionic liquid. Ronald T. Raines (2010). Abstracts of Papers of the American Chemical Society 240, Fuel Chemistry, 64.
2009

Publications—2009

Peer-Reviewed Journal Articles (Original Research)

  1. Coulombic effects on the traceless Staudinger ligation in water. Annie Tam and Ronald T. Raines (2009). Bioorganic & Medicinal Chemistry 17, 1055–1063. [PubMed] [PDF] [Supporting Information]
  2. Simple chemical transformation of lignocellulosic biomass into furanics for fuels and chemicals. Joseph B. Binder and Ronald T. Raines (2009). Journal of the American Chemical Society 131, 1979–1985. [PubMed] [PDF] [Supporting Information]
  3. Direct and continuous assay for prolyl 4-hydroxylase. Kelly L. Gorres and Ronald T. Raines (2009). Analytical Biochemistry 386, 181–185. [PubMed] [PDF]
  4. COVER ARTICLE A phosphine-mediated conversion of azides into diazo compounds. Eddie L. Myers and Ronald T. Raines (2009). Angewandte Chemie International Edition 48, 2359–2363. [PubMed] [PDF] [ [Supporting Information]
  5. Ribonuclease inhibitor regulates neovascularization by human angiogenin. Kimberly A. Dickson, Dong-Ku Kang, Young Sam Kwon, Jae Chan Kim, Peter A. Leland, Byung-Moon Kim, Soo-Ik Chang, and Ronald T. Raines (2009). Biochemistry 48, 3804–3806. [PubMed] [PDF] [Supporting Information]
  6. Nature of amide carbonyl–carbonyl interactions in proteins. Amit Choudhary, Deepa Gandla, Grant R. Krow, and Ronald T. Raines (2009). Journal of the American Chemical Society 131, 7244–7246. [PubMed] [PDF] [Supporting Information]
  7. Silencing an inhibitor unleashes a cytotoxic enzyme. Kimberly A. Dickson and Ronald T. Raines (2009). Biochemistry 48, 5051–5053. [PubMed] [PDF] [Supporting Information]
  8. ROMP from ROMP: A new approach to graft copolymer synthesis. Matthew J. Allen, Kittikhun Wangkanont, Ronald T. Raines, and Laura L. Kiessling (2009). Macromolecules 42 , 4023–4027. [PubMed] [PDF] [Supporting Information]
  9. Onconase cytotoxicity relies on the distribution of its positive charge. Rebecca F. Turcotte, Luke D. Lavis, and Ronald T. Raines (2009). FEBS Journal 276, 4270–4281. [PubMed] [PDF] [Supporting Information]
  10. Origin of the stability conferred upon collagen by fluorination. Matthew D. Shoulders, Kimberli J. Kamer, and Ronald T. Raines (2009). Bioorganic & Medicinal Chemistry Letters 19, 3859–3862. [PubMed] [PDF] [Supporting Information]
  11. Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells. Rex W. Watkins, Luke D. Lavis, Vanessa M. Kung, Georgyi V. Los, and Ronald T. Raines (2009). Organic & Biomolecular Chemistry 7, 969–975. [PubMed] [PDF] [Supporting Information]
  12. Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif. Urszula Derewenda, Tomasz Boczek, Kelly L. Gorres, Minmin Yu, Li-wei Hung, David Cooper, Andrzej Joachimiak, Ronald T. Raines, and Zygmunt S. Derewenda (2009). Biochemistry 48, 8664–8671. [PubMed] [PDF]
  13. 5(6)-anti-Substituted-2-azabicyclo[2.1.1]hexanes: A nucleophilic displacement route. Grant R. Krow, Ram Edupuganti, Deepa Gandla, Amit Choudhary, Guoliang Lin, Philip E. Sonnet, Charles DeBrosse, Charles W. Ross, III, Kevin C. Cannon, and Ronald T. Raines (2009). Journal of Organic Chemistry 74, 8232–8242. [PubMed] [PDF]
  14. Stringency of the 2-His–1-Asp active-site motif in prolyl 4-hydroxylase. Kelly L. Gorres, Khian Hong Pua, and Ronald T. Raines (2009). PLoS ONE 4, e7635. [PubMed] [PDF]
  15. 1,9-Bis(2-pyridyl)-1,2,8,9-tetrathia-5-oxanonane. Jeet Kalia and Ronald T. Raines (2009). Molbank, M642. [PubMed] [PDF]

Peer-Reviewed Journal Article (Review)

  1. Collagen structure and stability. Matthew D. Shoulders and Ronald T. Raines (2009). Annual Review of Biochemistry 78, 929–958. [PubMed] [PDF]

Invited Journal Article

  1. Protein engineering with the traceless Staudinger ligation. Annie Tam and Ronald T. Raines (2009). Methods in Enzymology 462, 25–44. [PubMed] [PDF]

Conference Proceedings

  1. Stronger and (now) longer synthetic collagen. Ronald T. Raines (2009). In Peptides for Youth: Proceedings of the 20th American Peptide Symposium (Emanuel Escher, William D. Lubell, and Susan Del Valle, Eds.), pp. xci–xcviii, Kluwer Academic, Norwell, MA. [PubMed] [PDF]
  2. Modulating collagen triple helix stability with 4-chloro-, 4-fluoro-, and 4-methylprolines. Matthew D. Shoulders and Ronald T. Raines (2009). In Peptides for Youth: Proceedings of the 20th American Peptide Symposium (Emanuel Escher, William D. Lubell, and Susan Del Valle, Eds.), pp. 251–252, Kluwer Academic, Norwell, MA. [PubMed] [PDF]
  3. A donor–acceptor perspective on carbonyl–carbonyl interactions in proteins. Amit Choudhary and Ronald T. Raines (2009). In Breaking Away: The Proceedings of the 21stAmerican Peptide Symposium (Michal Lebl, Ed.), pp. 347–349, Prompt Scientific Publishing, San Diego, CA. [PDF]

Abstracts

  1. QBI-139, a human RNase variant in a Phase I trial, has broad in vivo efficacy. Laura E. Strong, John A. Kink, Baigen Mei, Mark N. Shahan, Dan Pensinger, and Ronald T. Raines (2009). Molecular Cancer Therapeutics 8(12), Supplement 1, C42.
  2. Simple chemical transformation of lignocellulosic biomass into fuels and chemicals. Joseph B. Binder and Ronald T. Raines (2009). Abstracts of Papers of the American Chemical Society 237, Carbohydrate Chemistry, 61.
  3. Production of 5-hydroxymethylfurfural from carbohydrates in switchable solvent systems. Benjamin R. Caes, Joseph B. Binder, and Ronald T. Raines (2009). Abstracts of Papers of the American Chemical Society 237Organic Chemistry, 539.
  4. Determinants of collagen triple-helix stability in the Xaa position. Matthew D. Shoulders, Frank W. Kotch, and Ronald T. Raines (2009). Abstracts of Papers of the American Chemical Society 238, Organic Chemistry, 451.
2008

Publications—2008

Peer-Reviewed Journal Articles (Original Research)

  1. Structural basis for catalysis by onconase. J. Eugene Lee, Euiyoung Bae, Craig A. Bingman, George N. Phillips, Jr., and Ronald T. Raines (2008). Journal of Molecular Biology. 375, 165–177. [PubMed] [PDF]
  2. Trimethyl lock: A stable chromogenic substrate for esterases. Michael N. Levine, Luke D. Lavis, and Ronald T. Raines (2008). Molecules 13, 204–211. [PubMed] [PDF]
  3. 4-Chloroprolines: Synthesis, conformational analysis, and effect on the collagen triple helix. Matthew D. Shoulders, Ilia A. Guzei, and Ronald T. Raines (2008). Biopolymers 89, 443–454. [PubMed] [PDF]
  4. Stabilization of the collagen triple helix by O-methylation of hydroxyproline residues. Frank W. Kotch, Ilia A. Guzei, and Ronald T. Raines (2008). Journal of the American Chemical Society 130, 2952–2953. [PubMed] [PDF] [Supporting Information]
  5. Electronic and steric effects on the rate of the traceless Staudinger ligation. Annie Tam, Matthew B. Soellner, and Ronald T. Raines (2008). Organic & Biomolecular Chemistry 6, 1173–1175. [PubMed] [PDF] [Supporting Information]
  6. Genetic selection for peptide inhibitors of angiogenin. Bryan D. Smith and Ronald T. Raines (2008). Protein Engineering, Design & Selection 21, 289–294. [PubMed] [PDF] [Supporting Information]
  7. Self-assembled collagen-like peptide fibers as templates for metallic nanowires. Daniel Gottlieb, Stephen A. Morin, Song Jin, and Ronald T. Raines (2008). Journal of Materials Chemistry 18, 3865–3870. [PubMed] [PDF] [Supporting Information]
  8. Practical syntheses of 4-fluoroprolines. Mukund S. Chorghade, Debendra K. Mohapatra, Gokarneswar Sahoo, Mukund K. Gurjar, Manish V. Mandlecha, Nitin Bhoite, Santosh Moghe, and Ronald T. Raines (2008). Journal of Fluorine Chemistry 129, 781–784. [PubMed] [PDF]
  9. Conformational preferences of substrates for human prolyl 4-hydroxylase. Kelly L. Gorres, Ram Edupuganti, Grant R. Krow, and Ronald T. Raines (2008). Biochemistry 47, 9447–9455. [PubMed] [PDF]
  10. Hydrolytic stability of hydrazones and oximes. Jeet Kalia and Ronald T. Raines (2008).Angewandte Chemie International Edition 47, 7523–7526. [PubMed] [PDF] [Supporting Information]
  11. A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells. Melissa M. Yatzeck, Luke D. Lavis, Tzu-Yuan Chao, Sunil S. Chandran, and Ronald T. Raines (2008). Bioorganic & Medicinal Chemistry Letters 18, 5864–5866. [PubMed] [PDF] [Supporting Information]
  12. Interaction of onconase with the human ribonuclease inhibitor protein. Rebecca F. Turcotte and Ronald T. Raines (2008). Biochemical and Biophysical Research Communications 377, 512–514. [PubMed] [PDF]
  13. Design and characterization of an HIV-specific ribonuclease zymogen. Rebecca F. Turcotte and Ronald T. Raines (2008). AIDS Research and Human Retroviruses 24, 1357–1363. [PubMed] [PDF]

Peer-Reviewed Journal Articles (Reviews)

  1. Ribonucleases as novel chemotherapeutics: The ranpirnase example. J. Eugene Lee and Ronald T. Raines (2008). BioDrugs 22, 53–58. [PubMed] [PDF]
  2. Bright ideas for chemical biology. Luke D. Lavis and Ronald T. Raines (2008). ACS Chemical Biology 3, 142–155. [PubMed] [PDF] [Poster]
  3. Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity. Thomas J. Rutkoski and Ronald T. Raines (2008). Current Pharmaceutical Biotechnology 9, 185–199. [PubMed] [PDF]
  4. Olefin metathesis for chemical biology. Joseph B. Binder and Ronald T. Raines (2008). Current Opinion in Chemical Biology 12, 767–773. [PubMed] [PDF]

Commentaries

  1. Jeremy R. Knowles (1935–2008). Ronald T. Raines (2008). ACS Chemical Biology 3, 262–264. [PubMed] [PDF]
  2. Peptides and peptidomimetics as prototypes. Helma Wennemers and Ronald T. Raines (2008). Current Opinion in Chemical Biology 12, 690–691. [PubMed] [PDF]

Abstracts

  1. Design of Phase 1 trial of a human ribonuclease variant. Laura Strong, John A. Kink, Mark N. Shahan, Baigen Mei, and Ronald T. Raines (2008). Journal of Clinical Oncology 26 (May 20 Supplement), 14646.
  2. Latent fluorophores for biomolecular imaging. Ronald T. Raines (2008). FASEB Journal 22, 117.3.
  3. Substrate specificity and conformational preferences of prolyl 4-hydroxylase. Kelly L. Gorres and Ronald T. Raines (2008). FASEB Journal 22, 609.1.
  4. Antagonists of ribonuclease inhibitor: Small molecules, dendrimers, and peptides. Gregory A. Ellis, Luke D. Lavis, R. Jeremy Johnson, and Ronald T. Raines (2008). FASEB Journal 22, 651.1.
  5. Prenylation dependant localization of peptides and proteins in vivo. James W. Wollack, Nicholette A. Zeliadt, Margie T. Borra, Jinhwa A. Chung, Daniel G. Mullen, Stephen M. Fuchs, Ronald T. Raines, T. Andrew Taton, Elizabeth V. Wattenberg, Mark D. Distefano (2008). Abstracts of Papers of the American Chemical Society 236Biological Chemistry, 85.
  6. Fluorinated collagen as a biomaterial and in nanotechnology. Ronald T. Raines (2008). Abstracts of Papers of the American Chemical Society 236, Fluorine Chemistry, 18.
  7. Forces that stabilize the collagen triple helix. Matthew D. Shoulders and Ronald T. Raines (2008). Abstracts of Papers of the American Chemical Society 236, Medicinal Chemistry, 6.
2007

Publications—2007

Peer-Reviewed Journal Articles (Original Research)

  1. Is glycine a surrogate for a D-amino acid in the collagen triple helix? Jia-Cherng Horng, Frank W. Kotch, and Ronald T. Raines (2007). Protein Science 16, 208–215. [PubMed] [PDF]
  2. Salicylaldimine ruthenium alkylidene complexes: Metathesis catalysts tuned for protic solvents. Joseph B. Binder, Ilia A. Guzei, and Ronald T. Raines (2007). Advanced Synthesis & Catalysis 349, 395–404. [PubMed] [PDF]
  3. Multilayered films fabricated from an oligoarginine-conjugated protein promote efficient surface-mediated protein transduction. Christopher M. Jewell, Stephen M. Fuchs, Ryan M. Flessner, Ronald T. Raines, and David M. Lynn (2007). Biomacromolecules 8, 857–863. [PubMed] [PDF]
  4. Arginine grafting to endow cell-permeability. Stephen M. Fuchs and Ronald T. Raines (2007). ACS Chemical Biology 2, 167–170. [PubMed] [PDF] [Supporting Information]
  5. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. R. Jeremy Johnson, Jason G. McCoy, Craig A. Bingman, George N. Phillips, Jr., and Ronald T. Raines (2007). Journal of Molecular Biology 368, 434–449. [PubMed] [PDF]
  6. General method for site-specific protein immobilization by Staudinger ligation. Jeet Kalia, Nicholas L. Abbott, and Ronald T. Raines (2007). Bioconjugate Chemistry 18, 1064–1069. [PubMed] [PDF]
  7. Genetic selection to reveal the role of a buried, conserved polar residue. R. Jeremy Johnson, Shawn R. Lin, and Ronald T. Raines (2007). Protein Science 16, 1609–1616. [PubMed] [PDF]
  8. Tuning the pKa of fluorescein to optimize binding assays. Luke D. Lavis, Thomas J. Rutkoski, and Ronald T. Raines (2007). Analytical Chemistry 79, 6775–6782. [PubMed] [PDF] [Supporting Information]
  9. Cytotoxic ribonucleases: The dichotomy of Coulombic forces. R. Jeremy Johnson, Tzu-Yuan Chao, Luke D. Lavis, and Ronald T. Raines (2007). Biochemistry 46, 10308–10316. [PubMed] [PDF]
  10. Using measurements of anchoring energies of liquid crystals on surfaces to quantify protein capture by immobilized ligands. Thimmaiah Govindaraju, Paul J. Bertics, Ronald T. Raines, and Nicholas J. Abbott (2007). Journal of the American Chemical Society 129, 11223–11231. [PubMed] [PDF] [Supporting Information]
  11. Water-soluble phosphinothiols for traceless Staudinger ligation and integration with expressed protein ligation. Annie Tam, Matthew B. Soellner, and Ronald T. Raines (2007). Journal of the American Chemical Society 129, 11421–11430. [PubMed] [PDF] [Supporting Information]
  12. Protein prosthesis: 1,5-Disubstituted[1,2,3]triazoles as cis-peptide bond surrogates. Annie Tam, Ulrich Arnold, Matthew B. Soellner, and Ronald T. Raines (2007). Journal of the American Chemical Society 129, 12670–12671. [PubMed] [PDF] [Supporting Information]
  13. Catalysis of imido group hydrolysis in a maleimide conjugate. Jeet Kalia and Ronald T. Raines (2007). Bioorganic & Medicinal Chemistry Letters 17, 6286–6289. [PubMed] [PDF]
  14. Olefin metathesis in homogeneous aqueous media catalyzed by conventional ruthenium catalysts. Joseph B. Binder, Jacqueline J. Blank, and Ronald T. Raines (2007). Organic Letters 9, 4885–4888. [PubMed] [PDF] [Supporting Information]
  15. Intraspecies regulation of ribonucleolytic activity. R. Jeremy Johnson, Luke D. Lavis, and Ronald T. Raines (2007). Biochemistry 46, 13131–13140. [PubMed] [PDF] [Supporting Information]
  16. COVER ARTICLE Increasing the potency of a cytotoxin with an arginine graft. Stephen M. Fuchs, Thomas J. Rutkoski, Vanessa M. Kung, Ryan T. Groeschl, and Ronald T. Raines (2007). Protein Engineering, Design & Selection 20, 505–509. [PubMed] [PDF]

Peer-Reviewed Journal Article (Review)

  1. Liquid crystal-based analytic technology: Enabling a molecular view of cancer. Paul J. Bertics, Byram H. Ozer, Gregory J. Wiepz, Arturo G. Guadarrama, Nicholas L. Abbott, Aaron M. Lowe, Yiqun Bai, Eric V. Shusta, Nitin Agarwal, Ronald T. Raines, and Jeet Kalia (2007). BIOforum Europe 11, 42–45. [PDF]

Conference Proceeding

  1. Hyperstable collagen based on 4-fluoroproline residues. Ronald T. Raines (2007). In Current Fluoroorganic Chemistry: New Synthetic Directions, Technologies, Materials, and Biological Applications. ACS Symposium Series No. 949 (Vadim Anatol’evich Soloshonok, Koichi Mikami, Takashi Yamazaki, John T. Welch, and John F. Honek, Eds.), pp. 477–486, American Chemical Society, Washington, DC. [PDF]

Abstracts

  1. Modulating collagen triple helix stability with 4-chloro, 4-fluoro, and 4-methylprolines. Matthew D. Shoulders and Ronald T. Raines (2007). Biopolymers 88(4), 593.
  2. Toxicology of a potent human RNase variant. Laura E. Strong, John A. Kink, Mark N. Shahan, Beigen Mei, Kerry M. Ervin, and Ronald T. Raines (2007). Molecular Cancer Therapeutics 6, 3359S–3360S.
  3. Gd(III)-conjugates of ribonuclease A for in vivo transport studies. Matthew J. Allen, Thomas J. Rutkoski, Walter F. Block, Laura L. Kiessling, and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233, Inorganic Chemistry, 201.
  4. Salicylaldimine ruthenium alkylidene complexes: Metathesis catalysts tuned for protic solvents. Joseph B. Binder, Ilia A. Guzei, and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233Inorganic Chemistry, 380.
  5. Polymer-bound Gd(III)-chelates as contrast agents for magnetic resonance imaging. Matthew J. Allen, Walter F. Block, Ronald T. Raines, and Laura L. Kiessling (2007). Abstracts of Papers of the American Chemical Society 233, Inorganic Chemistry, 882.
  6. Net charge is not the primary determinant of onconase cytotoxicity. Rebecca F. Turcotte and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233, Medicinal Chemistry, 164.
  7. 1,5-Triazoles as cis peptide bond mimics. Annie Tam, Ulrich Arnold, Matthew B. Soellner, and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233, Organic Chemistry, 52.
  8. Toward synthetic collagen. Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233Organic Chemistry, 53–54.
  9. Azido-proteins: Semisynthesis and applications. Jeet Kalia and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233, Organic Chemistry, 647.
  10. Nanomaterials from self-assembling collagen building blocks. Daniel Gottlieb and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233, Organic Chemistry, 648.
  11. Synthetic probes for elucidating the mechanism of prolyl 4-hydroxylase. Kelly L. Gorres and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233, Organic Chemistry, 649.
  12. Contribution of a highly conserved serine residue to ribonuclease activity and stability. R. Jeremy Johnson, Shwan R. Lin, and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233, Organic Chemistry, 650.
  13. Tuning the pKa of fluorescein: Implications for binding assays. Luke D. Lavis , Thomas J. Rutkoski, and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233, Organic Chemistry, 651.
  14. Synthesis and characterization of diamino analog of dithiothreitol. Nicole M. McElfresh and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233, Organic Chemistry, 652.
  15. Effects of hydroxyl-group alkylation on hydroxyproline-containing collagen triple helices. Frank W. Kotch and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233, Organic Chemistry, 653.
  16. Synthesis of superbly hyperstable collagen triple helices via integration of steric and stereoelectronic effects. Matthew D. Shoulders and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 233,Organic Chemistry, 654.
  17. Intrinsic stability of common linkages used for bioconjugation. Jeet Kalia and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 234, Biological Chemistry, 53.
  18. Chemistry and biology of collagen. Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 234, Biological Chemistry, 112.
  19. Endowing ribonuclease with sequence specificity. Rex Watkins and Ronald T. Raines (2007). Abstracts of Papers of the American Chemical Society 234, Biological Chemistry, 122.
2006

Publications—2006

Peer-Reviewed Journal Articles (Original Research)

  1. COVER ARTICLE Stereoelectronic effects on polyproline conformation. Jia-Cherng Horng and Ronald T. Raines (2006). Protein Science 15, 74–83. [PubMed] [PDF]
  2. Self-assembly of synthetic collagen triple helices. Frank W. Kotch and Ronald T. Raines (2006). Proceedings of the National Academy of Sciences, U.S.A. 103, 3028–3033. [PubMed] [PDF] [Supporting Information]
  3. Semisynthesis and characterization of mammalian thioredoxin reductase. Brian Eckenroth, Katharine Harris, Anton A. Turanov, Vadim N. Gladyshev, Ronald T. Raines, and Robert J. Hondal (2006). Biochemistry 45, 5158–5170. [PubMed] [PDF]
  4. Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization. Matthew J. Allen, Ronald T. Raines, and Laura L. Kiessling. Journal of the American Chemical Society 128, 6534–6535. [PubMed] [PDF] [Supporting Information]
  5. Fluorogenic label for biomolecular imaging. Luke D. Lavis, Tzu-Yuan Chao, and Ronald T. Raines (2006). ACS Chemical Biology 1, 252–260. [PubMed] [PDF] [Supporting Information] [Movie]
  6. Reciprocity of steric and stereoelectronic effects in the collagen triple helix. Matthew D. Shoulders, Jonathan A. Hodges, and Ronald T. Raines (2006). Journal of the American Chemical Society 128, 8112–8113. [PubMed] [PDF] [Supporting Information]
  7. Reaction mechanism and kinetics of the traceless Staudinger ligation. Matthew B. Soellner, Bradley L. Nilsson, and Ronald T. Raines (2006). Journal of the American Chemical Society 128, 8820–8828. [PubMed] [PDF] [Supporting Information]
  8. Latent red and blue fluorophores based on the trimethyl lock. Luke D. Lavis, Tzu-Yuan Chao, and Ronald T. Raines (2006). ChemBioChem 7, 1151–1154. [PubMed] [PDF]
  9. Genetic selection for critical residues in ribonucleases. Bryan D. Smith and Ronald T. Raines (2006). Journal of Molecular Biology 362, 459–478. [PubMed] [PDF] [SuppInfo1] [SuppInfo2] [Movie]
  10. Characterization of protein immobilization at silver surfaces by near-edge X-ray absorptive fine structure spectroscopy. Xiaosong Liu, Chang-Hyun Jang, Fan Zheng, Astrid Jürgensen, J. D. Denlinger, Kimberly A. Dickson, Ronald T. Raines, Nicholas L. Abbott, and F. J. Himpsel (2006). Langmuir 22, 7719–7725. [PubMed] [PDF]
  11. Reactivity of intein thioesters: Appending a functional group to a protein. Jeet Kalia and Ronald T. Raines (2006). ChemBioChem 7, 1375–1383. [PubMed] [PDF]
  12. Synthesis and characterization of a novel class of reducing agents that are highly neuroprotective for retinal ganglion cells. Christopher R. Schlieve, Annie Tam, Bradley L. Nilsson, Christopher J. Lieven, Ronald T. Raines, and Leonard A. Levin (2006). Experimental Eye Research 83, 1252–1259. [PubMed] [PDF]
  13. Energetics of an n->π* interaction that impacts protein structure. Jonathan A. Hodges and Ronald T. Raines (2006). Organic Letters 8, 4695–4697. [PubMed] [PDF] [Supporting Information]
  14. Macrocyclic scaffold for the collagen triple helix. Jia-Cherng Horng, Andrew J. Hawk, Qian Zhao, Eric S. Benedict, and Steven D. Burke, and Ronald T. Raines (2006). Organic Letters 8, 4735–4738. [PubMed] [PDF] [Supporting Information]
  15. A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus. R. Jeremy Johnson, Shawn R. Lin, and Ronald T. Raines (2006). FEBS Journal 273, 5457–5465. [PubMed] [PDF]
  16. Staudinger ligation of peptides at non-glycyl residues. Matthew B. Soellner, Annie Tam, and Ronald T. Raines (2006). Journal of Organic Chemistry 71, 9824–9830. [PubMed] [PDF]

Peer-Reviewed Journal Articles (Reviews)

  1. 2005 Emil Thomas Kaiser award. Ronald T. Raines (2006). Protein Science 15, 1219–1225. [PubMed] [PDF]
  2. Internalization of cationic peptides: The road less (or more?) traveled. Stephen M. Fuchs and Ronald T. Raines (2006). Cellular and Molecular Life Sciences 63, 1819–1822. [PubMed] [PDF]
  3. Symbiosis: Chemical biology at Wisconsin. Laura L. Kiessling, Sally Garbo Wedde, and Ronald T. Raines (2006). ACS Chemical Biology 1, 481–484; 601. [PubMed] [PDF]

Conference Proceeding

  1. Self-assembly of collagen mimetic peptides. Frank W. Kotch and Ronald T. Raines (2006). In Understanding Biology Using Peptides: Proceedings of the 19th American Peptide Symposium (Sylvie E. Blondelle, Ed.), pp. 688–689, Springer, New York, NY. [PDF]

Abstracts

  1. Human RNase I variants are effective anti-cancer agents. Laura E. Strong, John A. Kink, Mark Shahan, K. Ervin, and Ronald T. Raines (2006). European Journal of Cancer Supplements 4, 125.
  2. Impact of charge on the cytotoxicity of human pancreatic ribonucleases. Jeremy R. Johnson, Tzu-Yuan Chao, Luke D. Lavis, Jason G. McCoy, George N. Phillips, Jr., and Ronald T. Raines (2006). Abstracts of Papers of the American Chemical Society 232, Biological Chemistry, 33.
  3. Fluorogenic label for biomolecular imaging. Luke D. Lavis, Tzu-Yuan Chao, and Ronald T. Raines (2006). Abstracts of Papers of the American Chemical Society 232, Biological Chemistry, 117.
  4. Hydroxypyridonate-based Gd(III)-chelates incorporated into ring-opening metathesis polymerization-derived polymers as sensitive imaging agents. Matthew J. Allen, Ronald T. Raines, and Laura L. Kiessling (2006). Abstracts of Papers of the American Chemical Society 232, Inorganic Chemistry, 695.
  5. Novel water-soluble aminophosphinothiol for traceless Staudinger ligation. Annie Tam, Matthew B. Soellner, and Ronald T. Raines (2006). Abstracts of Papers of the American Chemical Society 232, Organic Chemistry, 477.
2005

Publications—2005

Peer-Reviewed Journal Articles (Original Research)

  1. Synthetic surfaces for ribonuclease adsorption. Bryan D. Smith, Matthew B. Soellner, and Ronald T. Raines (2005). Langmuir 21, 187–190. [PubMed] [PDF]
  2. COVER ARTICLE O-Acylation of hydroxyproline residues: Effect on peptide bond isomerization and collagen stability. Cara L. Jenkins, Alexander I. McCloskey, Ilia A. Guzei, Eric S. Eberhardt, and Ronald T. Raines (2005). Peptide Science 80, 1–8. [PubMed] [PDF] [Supporting Information]
  3. Latent fluorophore based on the trimethyl lock. Sunil S. Chandran, Kimberly A. Dickson, and Ronald T. Raines (2005). Journal of the American Chemical Society 127, 1652–1653. [PubMed] [PDF] [Supporting Information]
  4. Binding of nonnatural 3′-nucleotides to ribonuclease A. Cara L. Jenkins, Nethaji Thiyagarajan, Rozamond Y. Sweeney, Michael P. Guy, Bradley R. Kelemen, K. Ravi Acharya, and Ronald T. Raines (2005). FEBS Journal 272, 744–755. [PubMed] [PDF]
  5. Polyarginine as a multifunctional fusion tag. Stephen M. Fuchs and Ronald T. Raines (2005). Protein Science 14, 1538–1544. [PubMed] [PDF]
  6. Peptide bond isosteres: Ester or (E)-alkene in the backbone of the collagen triple helix. Cara L. Jenkins, Melissa M. Vasbinder, Scott J. Miller, and Ronald T. Raines (2005). Organic Letters 7, 2619–2622. [PubMed] [PDF] [Supporting Information]
  7. Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases. Brian G. Miller and Ronald T. Raines (2005). Biochemistry 44, 10776–10783. [PubMed] [PDF]
  8. Catalysis of protein disulfide bond isomerization in a homogeneous substrate. Elizabeth A. Kersteen, Seth R. Barrows, and Ronald T. Raines (2005). Biochemistry 44, 12168–12178. [PubMed] [PDF]
  9. COVER ARTICLE Disruption of shape-complementarity markers to create cytotoxic variants of ribonuclease A. Thomas J. Rutkoski, Erin L. Kurten, Julie C. Mitchell, and Ronald T. Raines (2005). Journal of Molecular Biology 354, 41–54. [PubMed] [PDF]
  10. Stereoelectronic and steric effects in the collagen triple helix: Toward a code for strand association. Jonathan A. Hodges and Ronald T. Raines (2005). Journal of the American Chemical Society 127, 15923–15932. [PubMed] [PDF] [Supporting Information]
  11. Cytotoxicity of bovine seminal ribonuclease: Monomer versus dimer. J. Eugene Lee and Ronald T. Raines (2005). Biochemistry 44, 15760–15767. [PubMed] [PDF]

Peer-Reviewed Journal Articles (Reviews)

  1. Chemical synthesis of proteins. Bradley L. Nilsson, Matthew B. Soellner, and Ronald T. Raines (2005). Annual Review of Biophysics and Biomolecular Structure 34, 91–118. [PubMed] [PDF]
  2. Ribonuclease inhibitor: Structure and function. Kimberly A. Dickson, Marcia C. Haigis, and Ronald T. Raines (2005). Progress in Nucleic Acid Research and Molecular Biology 80, 349–374. [PubMed] [PDF]

Conference Proceeding

  1. Towards synthetic collagen. Ronald T. Raines (2005). In Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), pp. 181–182, American Chemical Society, New York, NY. [PDF]

Abstracts

  1. Synthesis and characterization of a novel class of thiol reducing agents which are highly neuroprotective for retinal ganglion cells. Christopher R. Schlieve, Bradley L. Nilsson, Ronald T. Raines, and Leonard A. Levin (2005). Investigative Opthamology & Visual Science 46, Supplement S, 188.
  2. Self-assembly of collagen mimetic peptides. Frank W. Kotch and Ronald T. Raines (2005). Biopolymers 80(4), P377.
  3. Chemical and biological engineering of proteins. Ronald T. Raines (2005). Abstracts of Papers of the American Chemical Society 229, Organic Chemistry, Part 2, 1.
  4. Towards synthetic collagen. Ronald T. Raines (2005). Abstracts of Papers of the American Chemical Society 229, Polymer Chemistry, Part 2, 155.
  5. Assembly and fibrillogenesis of collagen mimetic peptides. Frank W. Kotch and Ronald T. Raines (2005). Abstracts of Papers of the American Chemical Society 230, Organic Chemistry, 563.
2004

Publications—2004

Peer-Reviewed Journal Articles (Original Research)

  1. Glycosylation of onconase increases its conformational stability and toxicity for cancer cells. Byung-Moon Kim, Hana Kim, Ronald T. Raines, and Younghoon Lee (2004) Biochemical and Biophysical Research Communications 315, 976–983. [PubMed] [PDF]
  2. Pathway for polyarginine entry into mammalian cells. Stephen M. Fuchs and Ronald T. Raines (2004). Biochemistry 43, 2438–2444. [PubMed] [PDF]
  3. Identifying latent enzyme activities: Substrate ambiguity within modern bacterial sugar kinases. Brian G. Miller and Ronald T. Raines (2004). Biochemistry 43, 6387–6392. [PubMed] [PDF]
  4. Identifying latent enzyme activities: Substrate ambiguity within modern bacterial sugar kinases. Brian G. Miller and Ronald T. Raines (2004). Biochemistry 43, 6387–6392. [PubMed] [PDF]
  5. Imaging the binding ability of proteins immobilized on surfaces with different orientations by using liquid crystals. Yan-Yeung Luk, Matthew L. Tingey, Kimberly A. Dickson, Ronald T. Raines, and Nicholas L. Abbott (2004). Journal of the American Chemical Society 126, 9024–9032. [PubMed] [PDF]
  6. Production of human prolyl 4-hydroxylase in Escherichia coli. Elizabeth A. Kersteen, Joshua J. Higgin, and Ronald T. Raines (2004). Protein Expression & Purification 38, 279–291. [PubMed] [PDF]
  7. COVER ARTICLE Substituted 2-azabicyclo[2.1.1]hexanes constrained proline analogs: Implications for collagen stability. Cara L. Jenkins, Guoliang Lin, Jingqi Duo, Deepa Rapolu, Ilia A. Guzei, Ronald T. Raines, and Grant R. Krow (2004). Journal of Organic Chemistry 69, 8565–8573; 71, 1754. [PubMed] [PDF] [Supporting Information]

Conference Proceedings

  1. Protein assembly using the Staudinger ligation. Bradley L. Nilsson, Matthew B. Soellner, and Ronald T. Raines (2004). In Peptide Revolution: Genomics, Proteomics & Therapeutics: Proceedings of the 18th American Peptide Symposium (Michael Chorev and Tomi K. Sawyer, Eds.), pp. 278–279, Kluwer Academic, Norwell, MA. [PDF]
  2. Effect of 4-fluoroproline in the X-position on the stability of the collagen triple helix. Jonathan A. Hodges and Ronald T. Raines (2004). In Peptide Revolution: Genomics, Proteomics & Therapeutics: Proceedings of the 18th American Peptide Symposium (Michael Chorev and Tomi K. Sawyer, Eds.), pp. 472–473, Kluwer Academic, Norwell, MA. [PDF]

Book Chapters

  1. Active site of ribonuclease A. Ronald T. Raines (2004). In Artificial Nucleases (Marina A. Zenkova, Ed.), pp. 19–32, Springer–Verlag, Heidelberg, Germany. [PDF]
  2. Fluorescence gel retardation assay to detect protein–protein interactions. Sang-Hyun Park and Ronald T. Raines (2004). In Methods in Molecular Biology, vol. 261: Protein–Protein Interactions (Haian Fu, Ed.), pp. 155–160, Humana Press, Totowa, NJ. [PubMed] [PDF]
  3. Fluorescence polarization assay to quantify protein–protein interactions. Sang-Hyun Park and Ronald T. Raines (2004). In Methods in Molecular Biology, vol. 261: Protein–Protein Interactions (Haian Fu, Ed.), pp. 161–165, Humana Press, Totowa, NJ. [PubMed] [PDF]

Abstracts

  1. Neuroprotective effect of tris(2-carboxyethyl)phosphine (TCEP) in an optic nerve crush model in the rat. Kyle I. Swanson, Christopher R. Schlieve, Bradley L. Nilsson, Ronald T. Raines, and Leonard A. Levin (2004). Investigative Opthalmology & Visual Science 45, Supplement 1, 849.
  2. Chemical and biological engineering of enzymes. Ronald T. Raines (2004). Abstracts of Papers of the American Chemical Society 227, Medicinal Chemistry, Part 2, 214.
  3. Hypersensitive probes for in vitro and in vivo fluorescence assays of enzymatic activity. Sunil S. Chandran and Ronald T. Raines (2004). Abstracts of Papers of the American Chemical Society 227, Organic Chemistry, Part 2, 490.
  4. Staudinger ligation: Mechanistic studies and peptide immobilization. Matthew B. Soellner, Bradley L. Nilsson, Kimberly A. Dickson, and Ronald T. Raines (2004). Abstracts of Papers of the American Chemical Society 227, Organic Chemistry, Part 2, 493.
  5. RI evasion is a key factor in BS-RNase cytotoxicity. J. Eugene Lee and Ronald T. Raines (2004). Abstracts of Papers of the American Chemical Society 228, Biological Chemistry, Part 1, 106.
  6. Stereoelectronic effects on protein conformation. Ronald T. Raines (2004). Abstracts of Papers of the American Chemical Society 228, Organic Chemistry, Part 2, 275.
2003

Publications—2003

Peer-Reviewed Journal Articles (Research)

  1. Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. Marcia C. Haigis and Ronald T. Raines (2003). Journal of Cell Science 116, 313–324. [PubMed] [PDF]
  2. Creation of a zymogen. Parit Plainkum, Stephen M. Fuchs, Suthep Wiyakrutta, and Ronald T. Raines (2003). Nature Structural Biology 10, 115–119. [PubMed] [PDF]
  3. Ribonuclease inhibitor as an intracellular sentry. Marcia C. Haigis, Erin L. Kurten, and Ronald T. Raines (2003). Nucleic Acids Research 31, 1024–1032. [PubMed] [PDF]
  4. Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nucleotide. Joshua J. Higgin, Gennady I. Yakovlev, Vladimir A. Mitkevich, Alexander A. Makarov, and Ronald T. Raines (2003). Bioorganic & Medicinal Chemistry Letters 13, 409–412. [PubMed] [PDF]
  5. Catalysis by ribonuclease A is limited by the rate of substrate association. Chiwook Park and Ronald T. Raines (2003). Biochemistry 42, 3509–3518. [PubMed] [PDF] [Supporting Information]
  6. Protein assembly by orthogonal chemical ligation methods. Bradley L. Nilsson, Robert J. Hondal, Matthew B. Soellner, and Ronald T. Raines (2003). Journal of the American Chemical Society 125, 5268–5269. [PubMed] [PDF] [Supporting Information]
  7. The CXC motif: A functional mimic of protein disulfide isomerase. Kenneth J. Woycechowsky and Ronald T. Raines (2003). Biochemistry 42, 5387–5394. [PubMed] [PDF]
  8. An electronic effect on protein structure. Matthew P. Hinderaker and Ronald T. Raines (2003). Protein Science 12, 1188–1194. [PubMed] [PDF] [Supporting Information]
  9. Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, HO-1 and NOS-2 proteins in cultured neonatal cardiomyocytes. Gary Wright, Joshua J. Higgin, Ronald T. Raines, Charles Steenbergen, and Elizabeth Murphy (2003). Journal of Biological Chemistry 278, 20235–20239. [PubMed] [PDF]
  10. Effect of 3-hydroxyproline residues on collagen stability. Cara L. Jenkins, Lynn E. Bretscher, Ilia A. Guzei, and Ronald T. Raines (2003). Journal of the American Chemical Society 125, 6422–6427. [PubMed] [PDF] [Supporting Information]
  11. Potent inhibition of ribonuclease A by oligo(vinylsulfonic acid). Bryan D. Smith, Matthew B. Soellner, and Ronald T. Raines (2003). Journal of Biological Chemistry 278, 20934–20938. [PubMed] [PDF]
  12. Protein prosthesis: A nonnatural residue accelerates folding and increases stability. Ulrich Arnold, Matthew P. Hinderaker, Jens Köditz, Ralph Golbik, Renate Ulbrich-Hofmann, and Ronald T. Raines (2003). Journal of the American Chemical Society 125, 7500–7501. [PubMed] [PDF] [Supporting Information]
  13. COVER ARTICLE Compensating effects on the cytotoxicity of ribonuclease A variants. Kimberly A. Dickson, Caroline L. Dahlberg, and Ronald T. Raines (2003). Archives of Biochemistry and Biophysics 415, 172–177. [PubMed] [PDF]
  14. Catalysis of protein folding by an immobilized small-molecule dithiol. Kenneth J. Woycechowsky, Brad A. Hook, and Ronald T. Raines (2003). Biotechnology Progress 19, 1307–1314. [PubMed] [PDF]
  15. Stereoelectroniic effects on collagen stability: The dichotomy of 4-fluoroproline diastereomers. Jonathan A. Hodges and Ronald T. Raines (2003). Journal of the American Chemical Society 125, 9263–9264. [PubMed] [PDF] [Supporting Information]
  16. Site-specific protein immobilization by Staudinger ligation. Matthew B. Soellner, Kimberly A. Dickson, Bradley L. Nilsson, and Ronald T. Raines (2003). Journal of the American Chemical Society 125, 11790–11791. [PubMed] [PDF] [Supporting Information]
  17. Contribution of active-site residues to the function of onconase, a ribonuclease with antitumoral activity. J. Eugene Lee and Ronald T. Raines (2003). Biochemistry 42, 11443–11450. [PubMed] [PDF]
  18. Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease. J. Matousek, Josef Soucek, Tomas Slavik, Milan Tomanek, J. Eugene Lee, and Ronald T. Raines (2003). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 136, 343–356. [PubMed] [PDF]

Peer-Reviewed Journal Article (Review)

  1. Catalysis of disulfide bond formation by protein disulfide isomerase and small-molecule mimics. Elizabeth A. Kersteen and Ronald T. Raines (2003). Antioxidants & Redox Signalling 5, 414–424. [PubMed] [PDF]

Book Chapters

  1. Monitoring protein–protein interactions with GFP chimeras. Sang-Hyun Park and Ronald T. Raines (2003). In Protein Analysis: A Laboratory Manual (Richard Simpson, Ed.), pp. 766–771, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. [PDF]
  2. Protein assembly to mine the human genome. Bradley L. Nilsson, Matthew B. Soellner, and Ronald T. Raines (2003). In Chemical Probes in Biology, NATO ASI Series (Manfred P. Schneider, Ed.), pp. 359–369, Kluwer Academic Publishers, Dordrecht, The Netherlands. [PDF]

Abstracts

  1. Exploring the role of the ribonuclease inhibitor protein in angiogenesis. Kimberly A. Dickson, Peter A. Leland, and Ronald T. Raines (2003). Biochemistry 42(28), 28.
  2. Protein assembly using the Staudinger ligation. Bradley L. Nilsson, Matthew B. Soellner, and Ronald T. Raines (2003). Biopolymers 71(3), P002.
  3. Effect of fluoroproline in the X-position on the stability of the collagen triple helix. Jonathan A. Hodges and Ronald T. Raines (2003). Biopolymers 71(3), P032.
  4. Protein assembly using the Staudinger ligation. Bradley L. Nilsson, Matthew B. Soellner, and Ronald T. Raines (2003). Biopolymers 71(3), P159.
  5. Bioavailable inhibitors of prolyl 4-hydroxylase discovered by chemical genetics. Joshua J. Higgin, Lisa Friedman, and Ronald T. Raines (2003). Abstracts of Papers of the American Chemical Society 225, Medicinal Chemistry, Part 2, 137.
  6. Staudinger ligation: Kinetics and thermodynamics. Matthew B. Soellner, Bradley L. Nilsson, and Ronald T. Raines (2003). Abstracts of Papers of the American Chemical Society 225, Medicinal Chemistry, Part 2, 283.
  7. Comparison of the binding activity of randomly oriented and uniformly oriented proteins immobilized by chemoselective coupling to a self-assembled monolayer. Yan-Yeung Luk, Nicholas L. Abbott, Ronald T. Raines, Matthew L. Tingey, and Kimberly A. Dickson (2003). Abstracts of Papers of the American Chemical Society 226, Biological Chemistry, Part 1, 247. Also as Biochemistry 42(28), 247.
2002

Publications—2002

Peer-Reviewed Journal Articles (Research)

  1. Translocation of a β-peptide across cell membranes. Naoki Umezawa, Michael A. Gelman, Marcia C. Haigis, Ronald T. Raines, and Samuel H. Gellman (2002). Journal of the American Chemical Society 124, 368–369. [PubMed] [PDF] [Supporting Information]
  2. The ribonucleolytic activity of angiogenin. Peter A. Leland, Kristine E. Staniszewski, Chiwook Park, Bradley R. Kelemen, and Ronald T. Raines (2002). Biochemistry 41, 1343–1350. [PubMed] [PDF]
  3. Semisynthesis of ribonuclease A using intein-mediated protein ligation. Ulrich Arnold, Matthew P. Hinderaker, and Ronald T. Raines (2002). TheScientificWorldJOURNAL 2, 1823–1827. [PubMed] [PDF]
  4. Collagen stability: Insights from NMR spectroscopic and hybrid density functional computational investigations of the effect of electronegative substituents on prolyl ring conformations. Michele L. DeRider, Steven J. Wilkens, Michael J. Waddell, Lynn E. Bretscher, Frank Weinhold, Ronald T. Raines, and John L. Markley (2002). Journal of the American Chemical Society 124, 2497–2505. [PubMed] [PDF]
  5. KFERQ sequence in ribonuclease A-mediated cytotoxicity. Marcia C. Haigis, Erin L. Kurten, Richele L. Abel, and Ronald T. Raines (2002). Journal of Biological Chemistry 277, 11576–11581. [PubMed] [PDF]
  6. Evolution of ribonuclease inhibitor by exon duplication. Marcia C. Haigis, Eric S. Haag, and Ronald T. Raines (2002). Molecular Biology and Evolution 19, 960–964. [PubMed] [PDF]
  7. Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. Richele L. Abel, Marcia C. Haigis, Chiwook Park, and Ronald T. Raines (2002). Analytical Biochemistry 306, 100–107. [PubMed] [PDF]
  8. Staudinger ligation of α-azido acids retains stereochemistry. Matthew B. Soellner, Bradley L. Nilsson, and Ronald T. Raines (2002). Journal of Organic Chemistry 67, 4993–4996. [PubMed] [PDF] [Supporting Information]
  9. Protein prosthesis: A semisynthetic enzyme with a β-peptide reverse turn. Ulrich Arnold, Matthew P. Hinderaker, Bradley L. Nilsson, Bayard R. Huck, Samuel H. Gellman, and Ronald T. Raines (2002). Journal of the American Chemical Society 124, 8522–8523. [PubMed] [PDF] [Supporting Information]
  10. X-Ray structure of two crystalline forms of a Streptomycete ribonuclease with cytotoxic activity. Jozef Sevcik, Lubica Urbanikova, Peter A. Leland, and Ronald T. Raines (2002). Journal of Biological Chemistry 277, 47325–47330. [PubMed] [PDF]

Peer-Reviewed Journal Article (Review)

  1. Insights on the conformational stability of collagen. Cara L. Jenkins and Ronald T. Raines (2002). Natural Product Reports 19, 49–59. [PubMed] [PDF]

Invited Journal Articles

  1. Semisynthesis of proteins containing selenocysteine. Robert J. Hondal and Ronald T. Raines (2002). Methods in Enzymology 347, 70–83. [PubMed] [PDF]
  2. Genetic screen to dissect protein–protein interactions: Ribonuclease inhibitor–ribonuclease A as a model system. Sang-Hyun Park and Ronald T. Raines (2002). Methods 28, 346–352. [PubMed] [PDF]

Commentary

  1. This year’s model. Samuel H. Gellman and Ronald T. Raines (2002). Current Opinion in Chemical Biology 6, 727–728. [PDF]

Abstract

  1. Ribonuclease A: From model system to cancer chemotherapeutic. Ronald T. Raines (2002). Abstracts of Papers of the American Chemical Society 222, Physical Chemistry, Part 2, 124.
2001

Publications—2001

Peer-Reviewed Journal Articles (Research)

  1. High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide. Bradley L. Nilsson, Laura L. Kiessling, and Ronald T. Raines (2001). Organic Letters 3, 9–12. [PubMed] [PDF] [Supporting Information]
  2. Conformational stability of collagen relies on a stereoelectronic effect. Lynn E. Bretscher, Cara L. Jenkins, Kimberly M. Taylor, Michele L. DeRider, and Ronald T. Raines (2001). Journal of the American Chemical Society 123, 777–778. [PubMed] [PDF]
  3. Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding. Chiwook Park, L. Wayne Schultz, and Ronald T. Raines (2001). Biochemistry 40, 4949–4956. [PubMed] [PDF]
  4. Contribution of tertiary amides to the conformational stability of collagen triple helices. Elizabeth A. Kersteen and Ronald T. Raines (2001). Biopolymers 59, 24–28. [PubMed] [PDF]
  5. Selenocysteine in native chemical ligation and expressed protein ligation. Robert J. Hondal, Bradley L. Nilsson, and Ronald T. Raines (2001). Journal of the American Chemical Society 123, 5140–5141. [PubMed] [PDF] [Supporting Information]
  6. High-level soluble production and characterization of porcine ribonuclease inhibitor. Tony A. Klink, Anna M. Vicentini, Jan Hofsteenge, and Ronald T. Raines (2001). Protein Expression and Purification 22, 174–179. [PubMed] [PDF]
  7. Cleavage of 3′,5′-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin. Anwar M. Jardine, Demetres D. Leonidas, Jeremy L. Jenkins, Chiwook Park, Ronald T. Raines, K. Ravi Acharya, and Robert Shapiro (2001). Biochemistry 40, 10262–10272. [PubMed] [PDF]
  8. Quantitative analysis of the effect of salt concentration on enzymatic catalysis. Chiwook Park and Ronald T. Raines (2001). Journal of the American Chemical Society 123, 11472–11479. [PubMed] [PDF]
  9. Endowing human pancreatic ribonuclease with toxicity for cancer cells. Peter A. Leland, Kristine E. Staniszewski, Byung-Moon Kim, and Ronald T. Raines (2001). Journal of Biological Chemistry 276, 43095–43102. [PubMed] [PDF]
  10. Adjacent cysteine residues as a redox switch. Chiwook Park and Ronald T. Raines (2001). Protein Engineering 14, 939–942. [PubMed] [PDF]

Peer-Reviewed Journal Article (Review)

  1. Cancer chemotherapy–ribonucleases to the rescue. Peter A. Leland and Ronald T. Raines (2001). Chemistry & Biology 8, 405–413. [PubMed] [PDF]

Invited Journal Article

  1. Fast, facile, hypersensitive assays for ribonucleolytic activity. Chiwook Park, Bradley R. Kelemen, Tony A. Klink, Rozamond Y. Sweeney, Mark A. Behlke, Shad R. Eubanks, and Ronald T. Raines (2001). Methods in Enzymology 341, 81–94. [PubMed] [PDF]

Abstracts

  1. Semisynthesis of protein variants using intein-mediated protein ligation. Ulrich Arnold, Matthew P. Hinderaker, and Ronald T. Raines (2001). TheScientificWorldJOURNAL 1(S3), 117SR.
  2. Active-site variants of ribonuclease A. Richele L. Abel and Ronald T. Raines (2001). Biophysical Journal 80(1), Part 2, 1144.
  3. A ribonuclease zymogen as a chemotherapeutic for malaria. Parit Plainkum, Stephen M. Fuchs, and Ronald T. Raines (2001). FASEB Journal 15(4), Part 1, A538.
  4. Chemical genetics for the discovery of bioavailable ligands. Joshua J. Higgin, Lisa Friedman, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 221, Medicinal Chemistry, Part 2, 245.
  5. Selenocysteine in native chemical ligation and expressed protein ligation. Robert J. Hondal, Bradley L. Nilsson, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 9. Also as Biochemistry 40(29), 9.
  6. New assay for protein disulfide bond isomerization. Elizabeth A. Kersteen, Seth R. Barrows, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 34. Also as Biochemistry 40(29), 34.
  7. Contribution of individual modules of a leucine-rich repeat protein to its affinity for other proteins. Sunil S. Chandran, Kimberly A. Dickson, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 42. Also as Biochemistry 40(29), 42.
  8. Cytotoxic folate-targeted ribonuclease variants. Bryan D. Smith, Joshua J. Higgin, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 45. Also as Biochemistry 40(29), 45.
  9. Mechanism of ribonuclease cytotoxicity. Kimberly A. Dickson and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 71. Also as Biochemistry 40(29), 71.
  10. Ribonuclease A zymogen as a chemotherapeutic for malaria. Parit Plainkum, Stephen M. Fuchs, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 92. Also as Biochemistry 40(29), 92.
  11. Ribonuclease internalization. Marcia C. Haigis and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 93. Also as Biochemistry 40(29), 93.
  12. Role of lysine residues in the active site of onconase. J. H. Eugene Lee and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 94. Also as Biochemistry 40(29), 94.
  13. Semisynthesis of proteins containing non-natural modules. Ulrich Arnold, Matthew P. Hinderaker, Bradley L. Nilsson, Bayard R. Huck, Samuel H. Gellman, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 97. Also as Biochemistry 40(29), 97.
  14. Semisynthesis of proteins with novel covalent crosslinks. Matthew P. Hinderaker, Ulrich Arnold, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 98. Also as Biochemistry 40(29), 98.
  15. Stereochemical consequences of catalysis by ribonuclease A: Non-natural variants and phosphorothioate substrates. Robert J. Hondal, Richele L. Abel, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 172. Also as Biochemistry 40(29), 172.
  16. Active-site variants of ribonuclease A. Richele L. Abel, Robert J. Hondal, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 181. Also as Biochemistry 40(29), 181.
  17. Effect of guanidinium display on the translocation of molecules through membranes. Stephen M. Fuchs and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 213. Also as Biochemistry 40(29), 215.
  18. Effect of fluoroproline in the X-position on the triple-helical stability of collagen. Jonathan A. Hodges and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 224. Also as Biochemistry 40(29), 226.
  19. Factors affecting the conformational stability of collagen. Cara L. Jenkins, Lynn E. Bretscher, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Biological Chemistry, Part 1, 230. Also as Biochemistry 40(29), 232.
  20. Chemical genetics for the discovery of bioavailable prolyl 4-hydroxylase inhibitors. Joshua J. Higgin, Lisa Friedman, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Medicinal Chemistry, Part 1, 278.
  21. Peptide assembly by the Staudinger ligation. Bradley L. Nilsson, Laura L. Kiessling, and Ronald T. Raines (2001). Abstracts of Papers of the American Chemical Society 222, Organic Chemistry, Part 2, 484.
2000

Publications—2000

Peer-Reviewed Journal Articles (Research)

  1. Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A. Tony A. Klink, Kenneth J. Woycechowsky, Kimberly M. Taylor, and Ronald T. Raines (2000). European Journal of Biochemistry 267, 566–572. [PubMed] [PDF]
  2. Origin of the “inactivation” of ribonuclease A at low salt concentration. Chiwook Park and Ronald T. Raines (2000). FEBS Letters 468, 199–202. [PubMed] [PDF]
  3. A ribonuclease A variant with low catalytic activity but high cytotoxicity. Lynn E. Bretscher, Richele L. Abel, and Ronald T. Raines (2000). Journal of Biological Chemistry 275, 9893-9896. [PubMed] [PDF]
  4. Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans. Lisa Friedman, Joshua J. Higgin, Gary Moulder, Robert Barstead, Ronald T. Raines, and Judith Kimble (2000). Proceedings of the National Academy of Sciences, U.S.A. 97, 4736–4741. [PubMed] [PDF]
  5. Sulfur shuffle: Modulating enzymatic activity by thiol–disulfide interchange. June M. Messmore, Steven K. Holmgren, Juneko E. Grilley, and Ronald T. Raines (2000). Bioconjugate Chemistry 11, 408–413. [PubMed] [PDF]
  6. Conformational stability is a determinant of ribonuclease A cytotoxicity. Tony A. Klink and Ronald T. Raines (2000). Journal of Biological Chemistry 275, 17463–17467. [PubMed] [PDF]
  7. Staudinger ligation: A peptide from a thioester and azide. Bradley L. Nilsson, Laura L. Kiessling, and Ronald T. Raines (2000). Organic Letters 2, 1939–1941. [PubMed] [PDF] [Supporting Information]
  8. A synapomorphic disulfide bond is critical for the conformational stability and cytotoxicity of an amphibian ribonuclease. Peter A. Leland, Kristine E. Staniszewski, Byung-Moon Kim, and Ronald T. Raines (2000). FEBS Letters 477, 203–207. [PubMed] [PDF]
  9. Genetic selection for dissociative inhibitors of designated protein–protein interactions. Sang-Hyun Park and Ronald T. Raines (2000). Nature Biotechnology 18, 847–851. [PubMed] [PDF]
  10. Decavanadate inhibits catalysis by ribonuclease A. June M. Messmore and Ronald T. Raines (2000). Archives of Biochemistry and Biophysics 381, 25–30. [PubMed] [PDF]
  11. Effect of bovine seminal ribonuclease and its various forms on bovine oocyte maturation. Tomás Slavík, Josef Matousek, Josef Fulka, and Ronald T. Raines (2000). Journal of Experimental Zoology 287, 394–399. [PubMed] [PDF]
  12. Contribution of individual disulfide bonds to the oxidative folding of ribonuclease A. Margherita Ruoppolo, Floriana Vinci, Tony A. Klink, Ronald T. Raines, and Gennaro Marino (2000). Biochemistry 39, 12033–12042. [PubMed] [PDF]
  13. Pentavalent organo-vanadates as transition state analogues for phosphoryl transfer reactions. June M. Messmore and Ronald T. Raines (2000). Journal of the American Chemical Society 122, 9911–9916. [PubMed] [PDF]
  14. A highly active immobilized ribonuclease. Rozamond Y. Sweeney, Bradley R. Kelemen, Kenneth J. Woycechowsky, and Ronald T. Raines (2000). Analytical Biochemistry 286, 312–314. [PubMed] [PDF]
  15. COVER ARTICLE Dimer formation by a “monomeric” protein. Chiwook Park and Ronald T. Raines (2000). Protein Science 9, 2026–2033. [PubMed] [PDF]
  16. Excavating an active site: The nucleobase specificity of ribonuclease A. Bradley R. Kelemen, L. Wayne Schultz, Rozamond Y. Sweeney, and Ronald T. Raines (2000). Biochemistry 39, 14487–14494. [PubMed] [PDF]

Peer-Reviewed Journal Article (Review)

  1. Native disulfide bond formation in proteins. Kenneth J. Woycechowsky and Ronald T. Raines (2000). Current Opinion in Chemical Biology 4, 533–539. [PubMed] [PDF]

Invited Journal Articles

  1. The S-Tag fusion system for protein purification. Ronald T. Raines, Mark McCormick, Thomas R. Van Oosbree, and Robert C. Mierendorf (2000). Methods in Enzymology 326, 362–376. [PubMed] [PDF]
  2. Green fluorescent protein chimeras to probe protein–protein interactions. Sang-Hyun Park and Ronald T. Raines (2000). Methods in Enzymology 328, 251–261. [PubMed] [PDF]

Conference Proceedings

  1. The stereoelectronic basis of collagen stability. Ronald T. Raines, Lynn E. Bretscher, Steven K. Holmgren, and Kimberly M. Taylor (2000). In Peptides for the New Millennium: Proceedings of the 16th American Peptide Symposium (Gregg B. Fields, James P. Tam, and Geroge Barany, Eds.), pp. 344–346, Kluwer Academic, Dordrecht, The Netherlands. [PDF]
  2. Contribution of mainchain–mainchain hydrogen bonds to the conformational stability of triple-helical collagen. Mark A. Danielson and Ronald T. Raines (2000). In Peptides for the New Millennium: Proceedings of the 16th American Peptide Symposium (Gregg B. Fields, James P. Tam, and Geroge Barany, Eds.), pp. 347–348, Kluwer Academic, Dordrecht, The Netherlands. [PDF]
  3. Effect of fluoro-substituted proline residues on the conformational stability of triple-helical collagen mimics. Lynn E. Bretscher, Kimberly M. Taylor, and Ronald T. Raines (2000). In Peptides for the New Millennium: Proceedings of the 16th American Peptide Symposium (Gregg B. Fields, James P. Tam, and Geroge Barany, Eds.), pp. 355–356, Kluwer Academic, Dordrecht, The Netherlands. [PDF]
  4. Modulating the conformational stability of triple-helical collagen by chemical modification. Cara L. Jenkins, Kimberly M. Taylor, and Ronald T. Raines (2000). In Peptides for the New Millennium: Proceedings of the Sixteenth American Peptide Symposium (Gregg B. Fields, James P. Tam, and Geroge Barany, Eds.), pp. 357–358, Kluwer Academic, Dordrecht, The Netherlands. [PDF]

Abstract

  1. Ribonuclease A: From model system to cancer chemotherapeutic. Ronald T. Raines (2000). Italian Journal of Biochemistry 49(1), 13.
1999

Publications—1999

Peer-Reviewed Journal Articles (Original Research)

  1. Variants of ribonuclease inhibitor that resist oxidation. Byung-Moon Kim, L. Wayne Schultz, and Ronald T. Raines (1999). Protein Science 8, 430–434. [PubMed] [PDF]
  2. COVER ARTICLE A hyperstable collagen mimic. Steven K. Holmgren, Lynn E. Bretscher, Kimberly M. Taylor, and Ronald T. Raines (1999). Chemistry & Biology 6, 63–70. [PubMed] [PDF]
  3. His…Asp catalytic dyad of ribonuclease A: Histidine pKa values in the wild-type, D121N, and D121A enzymes. David J. Quirk and Ronald T. Raines (1999). Biophysical Journal 76, 1571–1579. [PubMed] [PDF]
  4. Extending the limits to enzymatic catalysis: Diffusion of ribonuclease A in one dimension. Bradley R. Kelemen and Ronald T. Raines (1999). Biochemistry 38, 5302–5307. [PubMed] [PDF]
  5. Structural changes to ribonuclease A and their effects on biological activity. Josef Soucek, Ronald T. Raines, Monika Haugg, Sun-Ai Raillard-Yoon, and Steven A. Benner (1999). Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 123, 103–111. [PubMed] [PDF]
  6. Hypersensitive substrate for ribonucleases. Bradley R. Kelemen, Tony A. Klink, Mark A. Behlke, Shad R. Eubanks, Peter A. Leland, and Ronald T. Raines (1999). Nucleic Acids Research 27, 3696–3701. [PubMed] [PDF]
  7. The CXXC motif: Crystal structure of an active-site variant of Escherichia coli thioredoxin. L. Wayne Schultz, Peter T. Chivers, and Ronald T. Raines (1999). Acta Crystallographica D55, 1533–1538. [PubMed] [PDF]
  8. A small-molecule catalyst of protein folding in vitro and in vivo. Kenneth J. Woycechowsky, K. Dane Wittrup, and Ronald T. Raines (1999). Chemistry & Biology 6, 871–879. [PubMed] [PDF]
  9. Chemical mechanism of DNA cleavage by the homing endonuclease I-PpoI. Stephen J. Mannino, Cara L. Jenkins, and Ronald T. Raines (1999). Biochemistry 38, 16178–16186. [PubMed] [PDF]

Conference Proceeding

  1. Ribonuclease A: From model system to cancer chemotherapeutic. Ronald T. Raines (1999). In Enzymatic Mechanisms: Proceedings of the 26th Steenbock Symposium (P. A. Frey and D. B. Northrop, Eds.), pp. 235–249, IOS Press, Washington, DC. [PDF]

Book Review

  1. Book Review. Biocalorimetry: Applications of Calorimetry in the Biological Sciences (John E. Ladbury and Babur Z. Chowdhry, Eds.) Kimberly M. Taylor and Ronald T. Raines (1999). FEBS Letters 459, 470–471. [PDF]
1998

Publications—1998

Peer-Reviewed Journal Articles (Original Research)

  1. Degenerate DNA recognition by I-PpoI endonuclease. Paula K. Wittmayer, Jennifer L. McKenzie, and Ronald T. Raines (1998). Gene 206, 11–21. [PubMed] [PDF]
  2. Code for collagen’s stability deciphered. Steven K. Holmgren, Kimberly M. Taylor, Lynn E. Bretscher, and Ronald T. Raines (1998). Nature 392, 666–667. [PubMed] [PDF]
  3. Structure and stability of the P93G variant of ribonuclease A. L. Wayne Schultz, Steven R. Hargraves, Tony A. Klink, and Ronald T. Raines (1998). Protein Science 7, 1620–1625. [PubMed] [PDF]
  4. Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments. Eric V. Shusta, Ronald T. Raines, Andreas Plückthun, and K. Dane Wittrup (1998). Nature Biotechnology 16, 773–777. [PubMed] [PDF]
  5. Coulombic forces in protein–RNA interactions: Binding and cleavage by ribonuclease A and variants at Lys7, Arg10, and Lys66. Barbra M. Fisher, Jeung-Hoi Ha, and Ronald T. Raines (1998). Biochemistry 37, 12121–12132. [PubMed] [PDF]
  6. Ribonuclease A variants with potent cytotoxic activity. Peter A. Leland, L. Wayne Schultz, Byung-Moon Kim, and Ronald T. Raines (1998). Proceedings of the National Academy of Sciences, U.S.A. 95, 10407–10412. [PubMed] [PDF]
  7. No role for pepstatin-A–sensitive proteinases in reovirus infections of L or MDCK cells. Subramanian Kothandaraman, Marcia C. Hebert, Ronald T. Raines, and Max L. Nibert (1998). Virology 251, 264–272. [PubMed] [PDF]
  8. Coulombic effects of remote subsites on the active site of ribonuclease A. Barbra M. Fisher, L. Wayne Schultz, Ronald T. Raines (1998). Biochemistry 37, 17386–17401. [PubMed] [PDF]
  9. A new remote subsite in ribonuclease A. Barbra M. Fisher, Juneko E. Grilley, Ronald T. Raines (1998). Journal of Biological Chemistry 273, 34134–34138. [PubMed] [PDF]
  10. His···Asp catalytic dyad of ribonuclease A: Conformational stability of the wild-type, D121N, D121A, and H119A enzymes. David J. Quirk, Chiwook Park, James E. Thompson, and Ronald T. Raines (1998). Biochemistry 37, 17958–17964. [PubMed] [PDF]

Peer-Reviewed Journal Article (Review)

  1. Ribonuclease A. Ronald T. Raines (1998). Chemical Reviews 98, 1045–1065. [PubMed] [PDF]

Book Chapter

  1. Protein disulfide isomerase: Cellular enzymology of the CXXC motif. Peter T. Chivers, Martha C. A. Laboissière, and Ronald T. Raines (1998). In Prolyl Hydroxylase, Protein Disulfide Isomerase, and Other Structurally Related Proteins (Norberto A. Guzman, Ed.), pp. 487–505. Marcel Dekker, New York. [PDF]

Book Review

  1. Book Review. Ribonucleases: Structures and Functions (Giuseppe D’Alessio and James F. Riordan, Eds.). Ronald T. Raines (1998). Protein Science 7, 804–805. [PDF]

Abstract

  1. Electronic structure effects on cis/trans peptide bond isomerizations of 4(S)-substituted prolyl derivatives. Michele L. DeRider, Steven J. Wilkens, Zeljko Dzakula, Ronald T. Raines, and John L. Markley (1998). Abstracts of Papers of the American Chemical Society 216, Computational Chemistry, Part 1, 117.
1997

Publications—1997

Peer-Reviewed Journal Articles (Original Research)

  1. The CXXC motif: A rheostat in the active site. Peter T. Chivers, Kenneth E. Prehoda, and Ronald T. Raines (1997). Biochemistry 36, 4061–4066. [PubMed] [PDF]
  2. Protein disulfide isomerase in spore germination and cell division. Martha C. A. Laboissiere, Stephen L. Sturley, and Ronald T. Raines (1997). Biological Chemistry 378, 431–437. [PubMed] [PDF]
  3. Green fluorescent protein as a signal for protein–protein interactions. Sang-Hyun Park and Ronald T. Raines (1997). Protein Science 6, 2344–2349. [PubMed] [PDF]
  4. Microscopic pKa Values of Escherichia coli thioredoxin. Peter T. Chivers, Kenneth E. Prehoda, Brian F. Volkman, Byung-Moon Kim, John L. Markley, and Ronald T. Raines (1997). Biochemistry 36, 14985–14991. [PubMed] [PDF]
  5. General acid/base catalysis in the active site of Escherichia coli thioredoxin. Peter T. Chivers and Ronald T. Raines (1997). Biochemistry 36, 15810–15816. [PubMed] [PDF]
  6. Ribonucleases endowed with specific toxicity for spermatogenic layers. Josef Matousek, Jin-Soo Kim, Josef Soucek, Jan Ríha, Marc Ribó, Peter A. Leland, and Ronald T. Raines (1997). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 118, 881–888. [PubMed] [PDF]

Book Chapter

  1. One-dimensional diffusion of a protein along a single-stranded nucleic acid. Bradley R. Kelemen and Ronald T. Raines (1997). In Techniques in Protein Chemistry VIII (Daniel R. Marshak, Ed.), pp. 565–572, Academic Press, New York. [PDF]

Commentary

  1. Nature’s transitory covalent bond. Ronald T. Raines (1997). Nature Structural Biology 4, 424–427. [PubMed] [PDF]
1996

Publications—1996

Peer-Reviewed Journal Articles (Original Research)

  1. Substrate binding and turnover by the highly specific I-PpoI endonuclease. Paula K. Wittmayer and Ronald T. Raines (1996). Biochemistry 35, 1076–1083. [PubMed] [PDF]
  2. Production of human pancreatic ribonuclease in Saccharomyces cerevisiae and Escherichia coli. Marc Ribó, Stephen B. delCardayré, Ronald T. Raines, Rafael de Llorens, and Claudi M. Cuchillo (1996). Protein Expression and Purification 7, 253–261. [PubMed] [PDF]
  3. The CXXC motif: Imperatives for the formation of native disulfide bonds in the cell. Peter T. Chivers, Martha C. A. Laboissiere, and Ronald T. Raines (1996). EMBO Journal 15, 2659–2667. [PubMed] [PDF]
  4. Immunosuppressive activity of bovine seminal ribonuclease and its mode of action. Josef Soucek, Iuri Marinov, Jíri Benes, Ivan Hilbert, Josef Matousek, and Ronald T. Raines (1996). Immunobiology 195, 271–285. [PubMed] [PDF]
  5. Inductive effects on the energetics of prolyl peptide bond isomerization: Implications for collagen folding and stability. Eric S. Eberhardt, Nicholas Panasik, Jr., and Ronald T. Raines (1996). Journal of the American Chemical Society 118, 12261–12266. [PubMed] [PDF]
  6. Contribution of a tyrosine side chain to ribonuclease A catalysis and stability. Eric S. Eberhardt, Paula K. Wittmayer, Barbra M. Templer, and Ronald T. Raines (1996). Protein Science 5, 1697–1703. [PubMed] [PDF]
1995

Publications—1995

Peer-Reviewed Journal Articles (Original Research)

  1. Dibromobimane as a fluorescent crosslinking reagent. Jin-Soo Kim and Ronald T. Raines (1995). Analytical Biochemistry 225, 174–176. [PubMed] [PDF]
  2. The extent to which ribonucleases cleave RNA. Stephen B. delCardayré and Ronald T. Raines (1995). Analytical Biochemistry 225, 176–178. [PubMed] [PDF]
  3. Structural basis for the biological activities of bovine seminal ribonuclease. Jin-Soo Kim, Josef Soucek, Josef Matousek, and Ronald T. Raines (1995). Journal of Biological Chemistry 270, 10525–10530. [PubMed] [PDF]
  4. Catalytic activity of bovine seminal ribonuclease is essential for its immunosuppressive and other biological activities. Jin-Soo Kim, Josef Soucek, Josef Matousek, and Ronald T. Raines (1995). Biochemistry Journal 308, 547–551. [PubMed] [PDF]
  5. Engineering ribonuclease A: Production, purification, and characterization of wild-type enzyme and mutants at Gln11. Stephen B. delCardayré, Marc Ribó, Erich M. Yokel, David J. Quirk, William J. Rutter, and Ronald T. Raines (1995). Protein Engineering 8, 261–273. [PubMed] [PDF]
  6. Replacing a surface loop endows ribonuclease A with angiogenic activity. Ronald T. Raines, Marian P. Toscano, David M. Nierengarten, Jeung Hoi Ha, and Robert Auerbach (1995). Journal of Biological Chemistry 270, 17180–17184. [PubMed] [PDF]
  7. Ribonuclease A: Revealing structure–function relationships with semisynthesis. June M. Messmore, Dana N. Fuchs, and Ronald T. Raines (1995). Journal of the American Chemical Society 117, 8057–8060. [PubMed] [PDF]
  8. Production of rat protein disulfide isomerase in Saccharomyces cerevisiae. Martha C. A. Laboissiere, Peter T. Chivers, and Ronald T. Raines (1995). Protein Expression and Purification 6, 700–706. [PubMed] [PDF]
  9. A residue to residue hydrogen bond mediates the nucleotide specificity of ribonuclease A. Stephen B. delCardayré and Ronald T. Raines (1995). Journal of Molecular Biology 252, 328–336. [PubMed] [PDF]
  10. Mechanism-based inactivation of ribonuclease A. Jeffrey K. Stowell, Theodore S. Widlanski, Tatiana G. Kutateladze, and Ronald T. Raines (1995). Journal of Organic Chemistry 60, 6930–6936. [PDF]
  11. The essential function of protein-disulfide isomerase is to unscramble non-native disulfide bonds. Martha C. A. Laboissiere, Stephen L. Sturley, and Ronald T. Raines (1995). Journal of Biological Chemistry 270, 28006–28009. [PubMed] [PDF]
  12. Limits to catalysis by ribonuclease A. James E. Thompson, Tatiana G. Kutateladze, Michael C. Schuster, Fernando D. Venegas, June M. Messmore, and Ronald T. Raines (1995). Bioorganic Chemistry 23, 471–481. [PDF]
  13. Mechanism of ribonuclease cytotoxicity. Jin-Soo Kim, Josef Soucek, Josef Matousek, and Ronald T. Raines (1995). Journal of Biological Chemistry 270, 31097–31102. [PubMed] [PDF]

Peer-Reviewed Journal Article (Education)

  1. COVER ARTICLE Analysis of receptor–ligand interactions. Alan D. Attie and Ronald T. Raines (1995). Journal of Chemical Education 72, 119–124. [PDF]
1994

Publications—1994

Peer-Reviewed Journal Articles (Original Research)

  1. Amide–amide and amide–water hydrogen bonds: Implications for protein folding and stability. Eric S. Eberhardt and Ronald T. Raines (1994). Journal of the American Chemical Society 116, 2149–2150. [PubMed] [PDF]
  2. Peptide tags for a dual affinity fusion system. Jin-Soo Kim and Ronald T. Raines (1994). Analytical Biochemistry 219, 165–166. [PubMed] [PDF]
  3. Structural determinants of enzymatic processivity. Stephen B. delCardayré and Ronald T. Raines (1994). Biochemistry 33, 6031–6037. [PubMed] [PDF]
  4. Value of general acid–base catalysis to ribonuclease A. James E. Thompson and Ronald T. Raines (1994). Journal of the American Chemical Society 116, 5467–5468. [PubMed] [PDF]
  5. Energetics of catalysis by ribonucleases: Fate of the 2′,3′-cyclic phosphodiester intermediate. James E. Thompson, Fernando D. Venegas, and Ronald T. Raines (1994). Biochemistry 33, 7408–7414. [PubMed] [PDF]
  6. A misfolded but active dimer of bovine seminal ribonuclease. Jin-Soo Kim and Ronald T. Raines (1994). European Journal of Biochemistry 224, 109–114. [PubMed] [PDF]
  7. Inductive effects on the structure of proline residues. Nicholas Panasik, Jr., Eric S. Eberhardt, Arthur S. Edison, Douglas R. Powell, and Ronald T. Raines (1994). International Journal of Peptide and Protein Research 44, 262–269. [PubMed] [PDF]

Book Chapter

  1. Altering substrate specificity and detecting processivity in nucleases. Stephen B. del Cardayré, James E. Thompson, and Ronald T. Raines (1994). In Techniques in Protein Chemistry V (John W. Crabb, Ed.), pp. 313–320. Academic Press, New York. [PDF]

Commentary

  1. S-Peptide in protein fusion systems: History and significance. Jin-Soo Kim and Ronald T. Raines (1994). inNovations 1, 5–6. [PDF]
1993

Publications—1993

Peer-Reviewed Journal Articles (Original Research)

  1. Ribonuclease S-peptide as a carrier in fusion proteins. Jin-Soo Kim and Ronald T. Raines (1993). Protein Science 2, 348–356. [PubMed] [PDF]
  2. Thermodynamic origin of prolyl peptide bond isomers. Eric S. Eberhardt, Stewart N. Loh, and Ronald T. Raines (1993). Tetrahedron Letters 34, 3055–3056. [PubMed] [PDF]
  3. RNS2: A senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation. Crispin B. Taylor, Pauline A. Bariola, Stephen B. delCardayré, Ronald T. Raines, and Pamela J. Green (1993). Proceedings of the National Academy of Sciences, U.S.A. 90, 5118–5122. [PubMed] [PDF]
  4. Bovine seminal ribonuclease produced from a synthetic gene. Jin-Soo Kim and Ronald T. Raines (1993). Journal of Biological Chemistry 268, 17392–17396. [PubMed] [PDF]

Abstracts

  1. Effect of electron withdrawal on prolyl peptide-bonds. Nicholas Panasik, Eric S. Eberhardt, and Ronald T. Raines (1993). Abstracts of Papers of the American Chemical Society 206, Organic Chemistry, Part 2, 294.
  2. Energies of amide–amide and water–amide hydrogen bonds. Eric S. Eberhardt and Ronald T. Raines (1993). Abstracts of Papers of the American Chemical Society 206, Organic Chemistry, Part 2, 295.
1992

Publications—1992

Peer-Reviewed Journal Article (Original Research)

  1. Solvent effects on the energetics of prolyl peptide bond isomerization. Eric S. Eberhardt, Stewart N. Loh, Andrew P. Hinck, and Ronald T. Raines (1992). Journal of the American Chemical Society 114, 5437–5439. [PubMed] [PDF] [Supporting Information]
1991

Publications—1991

Conference Proceedings

  1. Altering the residues of ribonuclease A. Ronald T. Raines (1991). In Metabolism and Enzymology of Nucleic Acids Including Gene and Protein Engineering: Proceedings of the Seventh International Symposium (Jozef Balan, Ed.), pp. 47–53, Slovak Academy of Sciences, Bratislava. [PDF]
  2. Altering the residues of ribonuclease A. Ronald T. Raines (1991). In Structure, Mechanism and Function of Ribonucleases: Proceedings of the Second International Meeting (Claudi M. Cuchillo, Rafael de Llorens, M. Victòria Nogués, and Xavier Parés, Eds.), pp. 139–143, Universitat Autonòma de Barcelona, Bellaterra, Spain. [PDF]

Abstract

  1. Triose phosphate isomerase mutants and mechanism—computation vs experiment. Dagmar Ringe, Paul Bash, Martin Karplus, Robert C. Davenport, Debra A. Giamonna, Shigetoshi Sugio, Zhidong Zhang, Gregory A. Petsko, Ronald T. Raines, Kathleen D. Liu, Elizabeth A. Komives, Patricia J. Lodi, and Jeremy R. Knowles (1991). FASEB Journal 5(5), Part 2, A1148.
1990

Publications—1990

Peer-Reviewed Journal Article (Education)

  1. Binding energy and enzymatic catalysis. David E. Hansen and Ronald T. Raines (1990). Journal of Chemical Education 67, 483–489. [PDF]
1989

Publications—1989

Peer-Reviewed Journal Article (Original Research)

  1. Evolutionary optimization of the catalytic effectiveness of an enzyme. Jonathan J. Burbaum, Ronald T. Raines, W. John Albery, and Jeremy R. Knowles (1989). Biochemistry 28, 9293–9305. [PubMed] [PDF]

Conference Proceeding

  1. Protein engineering of ribonuclease A. Ronald T. Raines and William J. Rutter (1989). In Structure and Chemistry of Ribonucleases: Proceedings of the First International Meeting (Alexander Pavlovsky and Kostya Polyakov, Eds.), pp. 95–100, Academy of Sciences of the USSR, Moscow. [PDF]
1988

Publications—1988

Peer-Reviewed Journal Article (Original Research)

  1. Triosephosphate isomerase catalysis is diffusion controlled. Stephen C. Blacklow, Ronald T. Raines, Wendell A. Lim, Philip D. Zamore, and Jeremy R. Knowles (1988). Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR. Wendell A. Lim, Ronald T. Raines, and Jeremy R. Knowles (1988). Biochemistry 27, 1158–1167. [PubMed] [PDF]

Peer-Reviewed Journal Article (Education)

  1. An intuitive approach to steady-state kinetics. Ronald T. Raines and David E. Hansen (1988). Journal of Chemical Education 65, 757–759. [PDF]
1987

Publications—1987

Peer-Reviewed Journal Articles (Original Research)

  1. Enzyme relaxation in the reaction catalyzed by triosephosphate isomerase: Detection and kinetic characterization of two unliganded forms of the enzyme. Ronald T. Raines and Jeremy R. Knowles (1987). Biochemistry 26, 7014–7020. [PubMed] [PDF]
  2. Kinetics and thermodynamics of the interaction of 5-fluoro-2′-deoxyuridylate with thymidylate synthase. Daniel V. Santi, Charles S. McHenry, Ronald T. Raines, and Kathryn M. Ivanetich (1987). Biochemistry 26, 8606–8613. [PubMed] [PDF]
1986

Publications—1986

Peer-Reviewed Journal Article (Original Research)

  1. Reaction energetics of a mutant triosephosphate isomerase in which the active-site glutamate has been changed to aspartate. Ronald T. Raines, Eliza L. Sutton, Donald R. Straus, Walter Gilbert, and Jeremy R. Knowles (1986). Biochemistry 25, 7142–7154. [PubMed] [PDF]

Conference Proceedings

  1. The mechanistic pathway of a mutant triosephosphate isomerase. Ronald T. Raines and Jeremy R. Knowles (1986). In Annals of the New York Academy of Sciences 471: International Symposium on Bioorganic Chemistry (Ronald Breslow, Ed.) pp. 266–272, New York Academy of Sciences, New York. [PubMed] [PDF]
  2. The kinetic consequences of altering the catalytic residues of triosephosphate isomerase. Ronald T. Raines, Donald R. Straus, Walter Gilbert, and Jeremy R. Knowles (1986). In Philosophical Transactions of the Royal Society London A 317: Design, Construction and Properties of Novel Protein Molecules (David M. Blow, Alan R. Fersht, and Greg Winter, Eds.) pp. 371–380, The Royal Society, London. [PDF]
1985

Publications—1985

Peer-Reviewed Journal Article (Original Research)

  1. Active site of triosephosphate isomerase: In vitro mutagenesis and characterization of an altered enzyme. Donald Straus, Ronald Raines, Eric Kawashima, Jeremy R. Knowles, and Walter Gilbert (1985). Proceedings of the National Academy of Sciences, U.S.A. 82, 2272–2276. [PubMed] [PDF]
1981

Publications—1981

Peer-Reviewed Journal Articles (Original Research)

  1. Mechanistic studies on reactions of bacterial methionine γ-lyase with olefinic amino acids. Michael Johnston, Ronald Raines, Michael Chang, Nobuyoshi Esaki, Kenji Soda, and Christopher Walsh (1981). Biochemistry 20, 4325–4333. [PubMed] [PDF]
  2. Mechanistic studies on the pyridoxal phosphate enzyme 1-aminocyclopropane-1-carboxylate deaminase from Pseudomonas sp. Christopher Walsh, Robert A. Pascal, Jr., Michael Johnston, Ronald Raines, Dinesh Dikshit, Allen Krantz, and Mamoru Honma (1981). Biochemistry 20, 7509–7519. [PubMed] [PDF]
1980

Publications—1980

Peer-Reviewed Journal Article (Original Research)

  1. Mechanism-based enzyme inactivation using an allyl sulfoxide–allyl sulfenate ester rearrangement. Michael Johnston, Ronald Raines, Christopher Walsh, and Raymond A. Firestone (1980). Journal of the American Chemical Society 102, 4241–4250. [PubMed] [PDF]
United States Patents
  1. 5,389,537 Nuclease having altered specificity. Ronald T. Raines and Stephen B. delCardayré (filed 01/21/1994; issued 02/14/1995).
  2. 5,817,455 Method for in vitro inactivation of RNase S. Ronald T. Raines (filed 04/29/1996; issued 10/06/1998).
  3. 5,840,296 Engineered cytotoxic ribonuclease A. Ronald T. Raines, Peter A. Leland, and L. Wayne Schultz (filed 10/15/1997; issued 11/24/1998).
  4. 5,910,435 Method of folding proteins with synthetic dithiol catalysts. Ronald T. Raines (filed 07/25/1996; issued 06/08/1999).
  5. 5,973,112 Collagen mimics. Ronald T. Raines (filed 08/25/1997; issued 10/26/1999).
  6. 6,280,991 Engineered cytotoxic ribonuclease. Ronald T. Raines (filed 11/24/1998; issued 08/28/2001).
  7. 6,833,489 Assays for modulators of prolyl 4-hydroxylase. Judith E. Kimble, Ronald T. Raines, and Lisa C. Friedman (filed 09/15/2000; issued 12/21/2004).
  8. 6,914,048 Method for delivery of molecules to intracellular targets. Samuel H. Gellman, Naoki Umezawa, Michael A. Gelman, Ronald T. Raines, Terra B. Potocky (filed 09/18/2002; issued 07/05/2005).
  9. 6,972,320 Ligation method and reagents to form an amide bond. Ronald T. Raines, Laura L. Kiessling, and Bradley L. Nilsson (filed 01/23/2003; issued 12/06/2005).
  10. 6,974,884 Chemical synthesis of reagents for peptide coupling. Ronald T. Raines, Laura L. Kiessling, Bradley L. Nilsson, Matthew B. Soellner, Yi He, and Ronald J. Hinklin (filed 06/06/2003; issued 12/13/2005).
  11. 7,098,016 Ribonuclease zymogen design. Ronald T. Raines, Parit Plainkum, and Stephen M. Fuchs (filed 06/13/2003; issued 08/29/2006).
  12. 7,122,521 Collagen mimics. Ronald T. Raines and Jonathan A. Hodges (filed 06/23/2003; issued 10/17/2006).
  13. 7,256,259 Methods for ligation of molecules to surfaces. Ronald T. Raines and Matthew B. Soellner (filed 08/30/2004; issued 08/14/2007).
  14. 7,317,129 Chemical synthesis of reagents for peptide coupling. Ronald T. Raines, Laura L. Kiessling, Bradley L. Nilsson, Matthew B. Soellner, Yi He, and Ronald J. Hinklin (filed 09/19/2005; issued 01/08/2008).
  15. 7,416,875 Cytotoxic ribonuclease variants. Ronald T. Raines, Julie C. Mitchell, and Thomas J. Rutkoski (filed 07/16/2006; issued 08/26/2008).
  16. 7,452,973 Cell-permeable fluorescent proteins. Ronald T. Raines and Stephen M. Fuchs (filed 11/07/2006; issued 11/18/2008).
  17. 7,534,902 Fluorescence assays with improved sensitivity. Ronald T. Raines, Sunil S. Chandran, Timothy E. Glass, and Luke D. Lavis (filed 11/15/2004; issued 05/19/2009).
  18. 7,560,248 Oxidation-resistant ribonuclease inhibitor. Ronald T. Raines (filed 01/20/1999; issued 07/14/2009).
  19. 7,655,757 Cytotoxic ribonuclease variants. Ronald T. Raines, George N. Phillips, Jr., R. Jeremy Johnson, and Jason G. McCoy (filed 06/16/2006; issued 02/02/2010).
  20. 7,807,140 Magnetic resonance imaging contrast agents synthesized using ring-opening metathesis polymerization. Laura L. Kiessling, Ronald T. Raines, and Matthew J. Allen (filed 05/03/2007; issued 10/05/2010).
  21. 7,858,741 Stabilization of the collagen triple helix by O-methylation of hydroxyproline residues. Ronald T. Raines and Frank W. Kotch (filed 02/06/2009; issued 12/28/2010).
  22. 7,863,301 Potentiators of insulin secretion. Alan D. Attie, Mary E. Rabaglia, Ronald T. Raines, and Mark Gray-Keller (filed 08/20/2004; issued 01/04/2011).
  23. 7,932,239 Methods of and compositions for reducing neuronal cell death. Ronald T. Raines and Leonard A. Levin (filed 04/27/2006; issued 04/26/2011).
  24. 7,973,132 Cell-permeable fluorescent proteins. Ronald T. Raines and Stephen M. Fuchs (filed 10/03/2008; issued 07/05/2011).
  25. 7,977,079 Nucleic acid constructs encoding cytotoxic ribonuclease variants. Ronald T. Raines, Julie C. Mitchell, and Thomas J. Rutkoski (filed 07/22/2008; issued 07/12/2011).
  26. 8,034,928 Fluorescence assays with improved sensitivity. Ronald T. Raines, Sunil S. Chandran, Timothy E. Glass, and Luke D. Lavis (filed 04/21/2009; issued 10/11/2011).
  27. 8,048,425 Cytotoxic ribonuclease variants. Ronald T. Raines, George N. Phillips, Jr., R. Jeremy Johnson, and Jason G. McCoy (filed 07/02/2009; issued 11/01/2011).
  28. 8,242,058 Reagents and methods for appending functional groups to proteins. Ronald T. Raines and Jeet Kalia (filed 07/23/2007; issued 08/14/2012).
  29. 8,247,190 Method for delivering cytotoxic activity to cells. Ronald T. Raines, Julie C. Mitchell, and Thomas J. Rutkoski (filed 07/11/2011; issued 08/21/2012).
  30. 8,293,872 Cytotoxic ribonuclease variants. Ronald T. Raines, George N. Phillips, Jr., R. Jeremy Johnson, Jason G. McCoy (filed 11/23/2011; issued 10/23/2012).
  31. 8,324,376 Chemical transformation of lignocellulosic biomass into fuels and chemicals. Joseph B. Binder and Ronald T. Raines (filed 06/16/2009; issued 12/04/2012).
  32. 8,350,014 Preparation of diazo and diazonium compounds. Ronald T. Raines and Eddie L. Myers (filed 11/17/2009; issued 01/08/2013).
  33. 8,410,247 Water-soluble phosphinothiol reagents. Ronald T. Raines, Annie Tam, and Matthew B. Soellner (filed 08/24/2009; issued 04/02/2013).
  34. 8,460,684 Nuclease inhibitors and methods for their use. Ronald T. Raines, Bryan D. Smith, Matthew B. Soellner, and David M. Lynn (filed 03/18/2005; issued 06/11/2013).
  35. 8,507,557 Potentiators of insulin secretion. Alan D. Attie, Mary E. Rabaglia, Ronald T. Raines, Mark Gray-Keller (filed 11/24/2010; issued 08/13/2013).
  36. 8,524,480 Cytotoxic ribonuclease variants. Ronald T. Raines, Julie C. Mitchell, and Thomas J. Rutkoski (filed 07/26/2012; issued 09/03/2013).
  37. 8,569,457 Cytotoxic ribonuclease variants. Ronald T. Raines, George N. Phillips, Jr., R. Jeremy Johnson, and Jason G. McCoy (filed 09/14/2012; issued 10/29/2013).
  38. 8,680,264 Chemical transformation of lignocellulosic biomass into fuels and chemicals. Joseph B. Binder and Ronald T. Raines (filed 10/30/2012; issued 03/25/2014).
  39. 8,697,062 Compositions and methods for ribonuclease-based therapeutics. Ronald T. Raines, Thomas J. Rutkoski, John A. Kink, and Laura E. Strong (filed 10/08/2008; issued 04/15/2014).
  40. 8,722,878 Biomass hydrolysis. Ronald T. Raines and Joseph B. Binder (filed 06/24/2010; issued 05/13/2014).
  41. 8,802,413 Cytotoxic ribonuclease variants. Ronald T. Raines, Julie C. Mitchell, and Thomas J. Rutkoski (filed: 08/13/2013; issued 08/12/2014).
  42. 8,834,918 Modified multilayered film. David M. Lynn, Ronald T. Raines, Christopher M. Jewell, Stephen M. Fuchs, and Ryan M. Flessner (filed 01/22/2008; issued 09/16/2014).
  43. 8,871,916 Diaryl phosphine compounds. Ronald T. Raines and Eddie L. Myers (filed 12/14/2012; issued 10/28/2014).
  44. 8,962,001 Nuclease inhibitors and methods for their use. Ronald T. Raines, Bryan D. Smith, Matthew B. Soellner, and David M. Lynn (filed 06/10/2013; issued 02/24/2015).
  45. 9,085,590 Protecting groups for boronic acids. Ronald T. Raines, Brett VanVeller, Matthew Aronoff (filed 03/14/2014; issued 07/21/2015).
  46. 9,090,662 Dithioamine reducing agents. Ronald T. Raines and John Lukesh (filed 02/15/2013; issued 07/28/2015).
  47. 9,162,999 Catalytic conversion of cellulose to fuels and chemicals using boronic acids. Ronald Raines, Benjamin Caes, and Michael Palte (filed 09/27/2012; issued 10/20/2015).
  48. 9,234,048 Boronate-mediated delivery of molecules into cells. Ronald T. Raines, Gregory Ellis, and Michael Palte (filed 01/18/2013; issued 01/12/2016).
  49. 9,234,191 Cytotoxic ribonuclease variants. Ronald T. Raines, George N. Phillips, Jr., Jeremy R. Johnson, and Jason G. McCoy (filed 10/04/2013; issued 01/12/2016).
  50. 9,255,260 Cytotoxic ribonuclease variants. Ronald T. Raines, George N. Phillips, Jr., Jeremy R. Johnson, and Jason G. McCoy (filed 07/18/2014; issued 02/09/2016).
  51. 9,371,521 Substituted pyrazinedithiol reducing agents. Ronald T. Raines and John C. Lukesh, III (filed 06/30/2014; issued 06/21/2016).
  52. 9,630,916 Organocatalysts of oxidative protein folding. Ronald T. Raines and John C. Lukesh, III (filed 08/19/2015; issued 04/25/2017).
  53. 9,732,101 Bioreversible boronates for delivery of molecules into cells. Ronald T. Raines and Thomas P. Smith (filed 07/27/2015; issued 08/15/2017).
  54. 9,738,664 Boronic acid inhibitors of HIV protease. Ronald T. Raines, Ian Windsor, Michael Palte, and John Lukesh (filed 10/29/2015; issued 08/22/2017).
  55. 9,758,569 Collagen mimics. Ronald T. Raines, Matthew D. Shoulders, and Jonathan A. Hodges (filed 05/25/2015; issued 08/22/2017).
  56. 9,790,483 Reagents and methods for esterification. Ronald T. Raines and Kalie Mix (filed 04/07/2016; issued 10/17/2017).
  57. 9,809,586 Inhibitors of collagen prolyl 4-hydroxylase. Ronald T. Raines and James Vasta (filed 03/28/2016; issued 11/07/2017).
  58. 9,988,434 Optimal interstrand bridge for collagen mimics. Ronald T. Raines and Ismet C. Tanrikulu (filed 09/11/2015; issued 06/05/2018).
  59. 10,258,695 Protein derivatization to endow cell penetration. Ronald T. Raines and Kristen A. Andersen (filed 09/03/2015; issued 04/16/2019).
  60. 10,329,341 Collagen mimics. Ronald T. Raines, Matthew D. Shoulders, and Jonathan A. Hodges (filed 08/02/2017; issued 06/25/2019).
  61. 10,428,323 Reagents and methods for esterification. Ronald T. Raines and Kalie Mix (filed 10/11/017; issued 10/01/2019).
  62. 10,577,303 Reagents and methods for esterification. Ronald T. Raines and Nicholas A. McGrath (filed 03/14/2013; issued 03/03/2020).
  63. 10,995,132 Optimal interstrand bridge for collagen mimics. Ronald T. Raines and Ismet C. Tanrikulu (filed 05/31/2018; issued 05/04/2021).
  64. 11,091,423 Reagents and methods for esterification. Ronald T. Raines and Nicholas A. McGrath (filed 02/03/2020; issued 08/17/2021).
  65. 11,180,748 Reagents and methods for esterification. Ronald T. Raines and Kalie Mix (filed 09/30/2019; issued 11/23/2021).
  66. 11,236,148 Method for the design of fibrillar collagen-mimetic peptide self-assemblies. Ronald T. Raines and Ismet Tanrikulu (filed 06/14/2017; issued 02/01/2022).
  67. 11,286,469 Combination chemotherapy for the treatment of cancer. Ronald T. Raines and Trish Hoang (filed 11/08/2018; issued 03/29/2022).
  68. 11,377,424 Cyclooctynes for click chemistry. Ronald T. Raines, Brian Gold, Jesús M. Dones, Nile S. Abularrage, and Brian J. Graham (filed 05/27/2021; issued 07/05/2022).
  69. 11,390,662 Collagen mimics. Ronald T. Raines, Matthew D. Shoulders, and Jonathan A. Hodges (filed 06/21/2019; issued 07/19/2022).
  70. 11,555,051 Dithioamine reducing agents. Ronald T. Raines and John Lukesh (filed 01/24/2019: issued 01/17/2023).
  71. 11,673,865 Cyclooctynes for click chemistry. Ronald T. Raines, Brian Gold, Jesus M. Dones, Nile S. Abularrage, and Brian James Graham (filed 04/29/2022; issued 06/13/2023).
  72. 11,884,619 Reagents and methods for esterification. Ronald T. Raines and Nicholas McGrath (filed 07/08/2021; issued 01/30/2024).
  73. 12,065,456 Boron-containing pharmacophore. Ronald T. Raines, Ian William Windsor, and Brian James Graham (filed 05/22/2020; issued 08/20/2024).
  74. 12,110,523 Reagents and methods for esterification. Ronald T. Raines and Kalie Mix (filed 11/15/2023; issued 10/08/2024).

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