WELCOME TO THE RAINES LAB

Chemistry to Understand and Control Life Processes

Find Out More…

Research

learn about our research

Publications

read about our discoveries

Team

see who works in our lab

Join

inquire about joining us at MIT

icon_chemistry

CHEMISTRY

We are developing powerful chemical methods to synthesize and modify proteins. In 2000, we invented the “traceless Staudinger ligation” to couple a peptide with a C-terminal phosphinothioester to one having an N-terminal azido group to form an amide bond. (An optimal reagent for mediating this ligation is…

Continue Reading

icon_biology

BIOLOGY

By understanding the underlying cellular processes, we are able to endow an otherwise innocuous human enzyme with clinically useful cytotoxicity. Ribonucleases catalyze the cleavage of RNA. Early-on, we made contributions to…

Continue Reading

icon_biomaterials

BIOMATERIALS

By exploiting the fundamental basis for the stability of collagen (which is the most abundant protein in humans), we are creating new materials to detect and treat wounds, tumors, and other abnormalities. For 25 years, the prevailing paradigm had been…

Continue Reading

Read About Our Discoveries

Our Team at MIT

raines-lab-mit-9-17-02018